边缘系统与单纯疱疹性脑炎的定位
The limbic system and the localisation of herpes simplex encephalitis.
作者信息
Damasio A R, Van Hoesen G W
出版信息
J Neurol Neurosurg Psychiatry. 1985 Apr;48(4):297-301. doi: 10.1136/jnnp.48.4.297.
Abstract
The selective destruction of temporal and frontal lobe structures by herpes simplex encephalitis has been explained as a consequence of the proximity of those regions to the point of entry of the virus in the encephalon, through olfactory pathways or meningeal branches of the trigeminal nerves. An alternative hypothesis is presented: that the encephalitis is due to a special affinity of the herpes simplex Type 1 virus for the limbic cortices, that is, that distinctive neuroanatomical, neurochemical and neuroimmunological properties of those cortices permit the virus to manifest its destructive behaviour, regardless of the route of entry to the CNS, possibly during altered immunological states. The study of the neurochemical and neuroimmunological properties of the limbic cortices may be a useful approach to the enigma of why and when herpes simplex Type 1 causes encephalitis.
摘要
单纯疱疹性脑炎对颞叶和额叶结构的选择性破坏，被解释为这些区域通过嗅觉通路或三叉神经的脑膜分支靠近病毒进入脑的部位的结果。本文提出了另一种假说：即脑炎是由于1型单纯疱疹病毒对边缘皮质具有特殊亲和力，也就是说，这些皮质独特的神经解剖学、神经化学和神经免疫学特性使病毒能够表现出其破坏性行为，而不论其进入中枢神经系统的途径如何，可能是在免疫状态改变期间。对边缘皮质的神经化学和神经免疫学特性的研究，可能是解开1型单纯疱疹病毒为何以及何时引发脑炎之谜的一种有用方法。
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