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Intracluster correlation coefficients from cluster randomized trials conducted within the NCI Community Oncology Research Program (NCORP).

作者信息

Snavely Anna C, Gunn Heather J, Lee Ju-Whei, Pugh Stephanie L, Barlow William E, Culakova Eva, Arnold Kathryn B, Kittel Carol A, Smith Sydney, Hanlon Bret M, Tan Angelina D, Dockter Travis, Zahrieh David, Dressler Emily V

机构信息

Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC 27103, United States.

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, United States.

出版信息

J Natl Cancer Inst Monogr. 2025 Mar 1;2025(68):65-72. doi: 10.1093/jncimonographs/lgae048.


DOI:10.1093/jncimonographs/lgae048
PMID:39989039
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11848034/
Abstract

The intracluster correlation coefficient (ICC) measures the correlation of observations within clusters and is a key parameter for power and sample size calculations for cluster randomized trials (CRTs). To facilitate the design of future CRTs within the National Cancer Institute Community Oncology Research Program (NCORP), all studies from the NCORP website were reviewed to identify completed CRTs. ICCs for primary and secondary outcomes (when available) were ascertained from these trials and summarized in this article as a resource for future trial development. Although ICCs are relatively small for many outcome cluster combinations, that is not always the case, so consideration should always be given to the specific outcome of interest, trial design, and type of cluster when estimating an ICC to facilitate trial development.

摘要

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