Snavely Anna C, Gunn Heather J, Lee Ju-Whei, Pugh Stephanie L, Barlow William E, Culakova Eva, Arnold Kathryn B, Kittel Carol A, Smith Sydney, Hanlon Bret M, Tan Angelina D, Dockter Travis, Zahrieh David, Dressler Emily V
Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC 27103, United States.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, United States.
J Natl Cancer Inst Monogr. 2025 Mar 1;2025(68):65-72. doi: 10.1093/jncimonographs/lgae048.
The intracluster correlation coefficient (ICC) measures the correlation of observations within clusters and is a key parameter for power and sample size calculations for cluster randomized trials (CRTs). To facilitate the design of future CRTs within the National Cancer Institute Community Oncology Research Program (NCORP), all studies from the NCORP website were reviewed to identify completed CRTs. ICCs for primary and secondary outcomes (when available) were ascertained from these trials and summarized in this article as a resource for future trial development. Although ICCs are relatively small for many outcome cluster combinations, that is not always the case, so consideration should always be given to the specific outcome of interest, trial design, and type of cluster when estimating an ICC to facilitate trial development.
J Natl Cancer Inst Monogr. 2025-3-1
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Cochrane Database Syst Rev. 2008-7-16
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