Hick J F, Block D J, Ilstrup D M
J Pediatr Ophthalmol Strabismus. 1985 May-Jun;22(3):92-3. doi: 10.3928/0191-3913-19850501-04.
The caustic property of silver nitrate prompted a double-blind, controlled study of a possible causal relationship between use of the agent for prophylaxis against ophthalmic infection in the newborn and the subsequent development of nasolacrimal duct obstruction. Follow-up of 145 newborns randomized either to 1% silver nitrate prophylaxis or to 1% tetracycline prophylaxis revealed no statistically significant difference in the incidence of nasolacrimal duct obstruction between the two groups at either two weeks or two months of age. It is concluded that silver nitrate prophylaxis does not predispose to nasolacrimal duct obstruction in the newborn.
硝酸银的腐蚀性促使人们开展了一项双盲对照研究，以探究在新生儿中使用该药物预防眼部感染与随后发生鼻泪管阻塞之间是否存在因果关系。对145名新生儿进行随机分组，一组接受1%硝酸银预防治疗，另一组接受1%四环素预防治疗，结果显示，在两周龄和两月龄时，两组鼻泪管阻塞的发生率在统计学上均无显著差异。研究得出结论，硝酸银预防治疗不会使新生儿易患鼻泪管阻塞。
