Celesti Consuelo, Iannazzo Daniela, Piperopoulos Elpida, Gabriele Bartolo, Mancuso Raffaella, Visalli Giuseppa, Facciolà Alessio, Laganà Antonio
Department of Engineering, University of Messina, Messina, Contrada Di Dio I-98166, Italy.
Laboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Via Pietro Bucci 12/C, Arcavacata di Rende (CS) 87036, Italy.
ACS Omega. 2025 Feb 5;10(6):5582-5592. doi: 10.1021/acsomega.4c08503. eCollection 2025 Feb 18.
Bacterial colonization of titanium-based materials used in implantable medical devices represents a significant challenge in the dental and orthopedic fields, often leading to infections and implant failure. This study reports the surface modification of titanium discs with ammonium salts containing carbon atom chains of different lengths (from 6 to 12) to provide antibacterial properties to the modified metal surfaces while maintaining their biocompatibility. The chemically modified samples have been characterized by ATR-FTIR and SEM-EDX analyses and evaluated for roughness and hydrophilic behavior. This surface modification not only provides hydrophobic properties to titanium surfaces but also introduces a hindering environment for bacterial adhesion. Antibacterial tests performed against methicillin-sensitive and methicillin-resistant strains demonstrated a proportional increase in antibacterial activity with increasing carbon chain length. The best antibacterial performance is reported for the sample containing 12 carbon atoms (Ti-ADTEAB), which showed inhibition values of 87.5 and 86.6% for the sensitive and resistant strains, respectively. The results suggest that this surface modification could lead to a new generation of implantable medical devices with improved patient outcomes by reducing the risk of postoperative infections.
用于植入式医疗设备的钛基材料的细菌定植是牙科和骨科领域的一项重大挑战，常常导致感染和植入失败。本研究报告了用含不同长度（6至12个）碳原子链的铵盐对钛盘进行表面改性，以使改性金属表面具有抗菌性能，同时保持其生物相容性。通过ATR-FTIR和SEM-EDX分析对化学改性样品进行了表征，并对粗糙度和亲水行为进行了评估。这种表面改性不仅赋予钛表面疏水性能，还为细菌粘附引入了阻碍环境。针对甲氧西林敏感和耐甲氧西林菌株进行的抗菌测试表明，抗菌活性随碳链长度增加呈比例增加。含12个碳原子的样品（Ti-ADTEAB）表现出最佳抗菌性能，对敏感菌株和耐药菌株的抑制值分别为87.5%和86.6%。结果表明，这种表面改性可通过降低术后感染风险，带来新一代具有改善患者预后的植入式医疗设备。
