Hasson J E, Megerman J, Abbott W M
J Vasc Surg. 1985 May;2(3):419-23.
Mismatch in mechanical properties (compliance mismatch) between host artery and prosthetic graft has been suggested as a cause of graft failure, but no mechanism linking the two has been identified. With the use of a simplified model based on isocompliant arterial grafts, pulsed ultrasound was used to generate detailed longitudinal profiles of diameter and compliance near the anastomoses. These longitudinal profiles revealed that although arterial diameter decreases monotonically to a minimal level at an anastomosis, arterial compliance first increases by approximately 50% before decreasing to 60% of the control value. This para-anastomotic hypercompliant zone (PHZ) is centered 3.6 mm from the anastomosis. PHZ also occurs in the artery adjacent to compliant or stiff grafts and is probably caused by transmitted effects of the suture line on the arterial wall. PHZ adds to any mismatch in compliance that already exists between artery and graft and can produce a compliance mismatch even between an artery and a nominally isocompliant prosthetic graft. It is hypothesized that PHZ, a region of increased cyclic stretch, promotes subintimal hyperplasia near anastomoses and may thus be a link between the mechanical properties of arteries and the failure of bypass grafts.
宿主动脉与人工血管之间的机械性能不匹配（顺应性不匹配）被认为是血管移植失败的一个原因，但尚未确定两者之间的联系机制。利用基于等顺应性动脉移植物的简化模型，使用脉冲超声生成吻合口附近直径和顺应性的详细纵向剖面图。这些纵向剖面图显示，尽管动脉直径在吻合口处单调减小至最小水平，但动脉顺应性在减小至对照值的60%之前首先增加约50%。这个吻合口旁高顺应性区域（PHZ）以距吻合口3.6毫米为中心。PHZ也出现在顺应性或僵硬移植物相邻的动脉中，可能是由缝线对动脉壁的传递效应引起的。PHZ增加了动脉与移植物之间已经存在的顺应性不匹配，甚至可能在动脉与名义上的等顺应性人工血管之间产生顺应性不匹配。据推测，PHZ作为一个循环拉伸增加的区域，会促进吻合口附近的内膜下增生，因此可能是动脉机械性能与旁路移植失败之间的一个联系。
