Matalon Sadis
Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, Heersink School of Medicine UAB | The University of Alabama at Birmingham, Birmingham, Alabama, United States.
Am J Physiol Cell Physiol. 2025 May 1;328(5):C1526-C1534. doi: 10.1152/ajpcell.00030.2025. Epub 2025 Feb 24.
It was an honor to be asked to deliver the Walter B. Cannon Lecture during the 2024 American Physiological Summit meeting. Dr. Cannon served as president of the American Physiological Society from 1914-1916. He coined the term "fight or flight" to describe an animal's response to threats and the concept of Homeostasis. He was the consummate physician-scientist, an outstanding mentor and teacher, a prolific writer, and a humanitarian. The title of my lecture is based on a poem entitled "Ithaca," written by the Greek poet C. P. Cavafy, who recounts the 10 yr travels of Ulysses, from Troy to his home, Ithaca. Odysseus had to overcome many obstacles to survive this long journey. Like Odysseus, I encountered myriad of professional and health problems. But, I also have experienced the thrill of contributing to scientific knowledge, the satisfaction of watching my mentees develop into independent scientists, the excitement of teaching respiration physiology to medical and professional students, and the pleasure of being of service to my discipline by serving as Editor of the American Journal of Physiology-Lung Cellular and Molecular Physiology and of Physiological Reviews. During my career, I have been interested in identifying the basic mechanisms by which oxidant gases and pathogens damage the blood gas barrier resulting in acute and chronic lung injury. In this brief review, I summarize the results of current studies implicating free heme as a major mediator of acute lung injury and our efforts to develop recombinant forms of human hemopexin, as a countermeasure.
很荣幸受邀在2024年美国生理学会峰会上发表沃尔特·B·坎农讲座。坎农博士在1914年至1916年期间担任美国生理学会会长。他创造了“战斗或逃跑”一词来描述动物对威胁的反应以及内稳态的概念。他是一位完美的医生科学家、杰出的导师和教师、多产的作家，也是一位人道主义者。我讲座的标题基于希腊诗人C.P.卡瓦菲斯所写的一首名为《伊萨卡》的诗，诗中讲述了尤利西斯从特洛伊到他的家乡伊萨卡的十年旅程。奥德修斯必须克服许多障碍才能在这段漫长的旅程中生存下来。和奥德修斯一样，我也遇到了无数的职业和健康问题。但是，我也体验到了为科学知识做出贡献的兴奋、看着我的 mentees 成长为独立科学家的满足、向医学生和专业学生教授呼吸生理学的激动，以及通过担任《美国生理学杂志 - 肺细胞与分子生理学》和《生理学评论》的编辑为我的学科服务的乐趣。在我的职业生涯中，我一直对确定氧化气体和病原体破坏血气屏障导致急性和慢性肺损伤的基本机制感兴趣。在这篇简短的综述中，我总结了当前研究的结果，这些结果表明游离血红素是急性肺损伤的主要介质，以及我们开发重组形式的人血红素结合蛋白作为一种对策的努力。
