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Microfluidic Flow Promotes a Steatotic Phenotype in Induced Pluripotent Stem Cell-Derived Hepatocytes that is Influenced by Disease State of the Donor.

作者信息

Minocha Ekta, Jiang Linan, Gupta Ashwani Kumar, Green Richard M, Zohar Yitshak, Wertheim Jason A

机构信息

Department of Surgery, University of Arizona College of Medicine, Tucson, Arizona.

Surgery Service, Southern Arizona VA Health Care System, Tucson, Arizona.

出版信息

Gastro Hep Adv. 2024 Dec 15;4(4):100601. doi: 10.1016/j.gastha.2024.100601. eCollection 2025.

DOI:10.1016/j.gastha.2024.100601
PMID:39996239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11849064/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c2/11849064/2743f16bd8aa/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c2/11849064/a8f62cf01e97/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c2/11849064/a5cfd7179622/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c2/11849064/40b5e4515c33/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c2/11849064/2743f16bd8aa/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c2/11849064/a8f62cf01e97/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c2/11849064/a5cfd7179622/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c2/11849064/40b5e4515c33/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c2/11849064/2743f16bd8aa/figs2.jpg

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本文引用的文献

1
Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile.非酒精性脂肪性肝病患者诱导多能干细胞来源的肝细胞表现出疾病特异性基因表达谱。
Gastroenterology. 2021 Jun;160(7):2591-2594.e6. doi: 10.1053/j.gastro.2021.02.050. Epub 2021 Feb 25.
2
Human Nonalcoholic Steatohepatitis on a Chip.人源非酒精性脂肪性肝炎芯片模型。
Hepatol Commun. 2020 Nov 29;5(2):217-233. doi: 10.1002/hep4.1647. eCollection 2021 Feb.
3
A microfluidic patterned model of non-alcoholic fatty liver disease: applications to disease progression and zonation.
一种非酒精性脂肪性肝病的微流控图案模型：在疾病进展和分区中的应用。
Lab Chip. 2019 Sep 10;19(18):3022-3031. doi: 10.1039/c9lc00354a.
4
Fabrication of a co-culture micro-bioreactor device for efficient hepatic differentiation of human induced pluripotent stem cells (hiPSCs).用于高效人诱导多能干细胞（hiPSCs）肝向分化的共培养微生物反应器装置的构建。
Artif Cells Nanomed Biotechnol. 2018;46(sup2):161-170. doi: 10.1080/21691401.2018.1452753. Epub 2018 Apr 27.
5
Non-autonomous multi-rogue waves for spin-1 coupled nonlinear Gross-Pitaevskii equation and management by external potentials.非自治多棘波对自旋-1 耦合非线性 Gross-Pitaevskii 方程的影响及外部势的控制。
Sci Rep. 2017 Sep 6;7(1):10638. doi: 10.1038/s41598-017-10205-4.
6
Microfluidic organs-on-chips.微流控器官芯片。
Nat Biotechnol. 2014 Aug;32(8):760-72. doi: 10.1038/nbt.2989.
7
Differentiation of hepatocytes from pluripotent stem cells.从多能干细胞分化肝细胞。
Curr Protoc Stem Cell Biol. 2013 Sep 20;26:1G.4.1-1G.4.13. doi: 10.1002/9780470151808.sc01g04s26.
8
Role of hepatic progenitor cells in nonalcoholic fatty liver disease development: cellular cross-talks and molecular networks.肝祖细胞在非酒精性脂肪性肝病发展中的作用：细胞串扰和分子网络。
Int J Mol Sci. 2013 Oct 9;14(10):20112-30. doi: 10.3390/ijms141020112.
9
Organotypic liver culture models: meeting current challenges in toxicity testing.器官型肝培养模型：应对当前毒性测试的挑战。
Crit Rev Toxicol. 2012 Jul;42(6):501-48. doi: 10.3109/10408444.2012.682115. Epub 2012 May 15.