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Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile.

作者信息

Duwaerts Caroline C, Le Guillou Dounia, Her Chris L, Phillips Nathaniel J, Willenbring Holger, Mattis Aras N, Maher Jacquelyn J

机构信息

Department of Medicine, University of California San Francisco, San Francisco, California; The Liver Center, University of California San Francisco, San Francisco, California.

Technology Center for Genomics & Bioinformatics, University of California Los Angeles, Los Angeles, California.

出版信息

Gastroenterology. 2021 Jun;160(7):2591-2594.e6. doi: 10.1053/j.gastro.2021.02.050. Epub 2021 Feb 25.

DOI:10.1053/j.gastro.2021.02.050
PMID:33640436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8169560/
Abstract
摘要

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本文引用的文献

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Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease.人多能干细胞衍生类器官作为肝脏疾病模型。
Gastroenterology. 2020 Oct;159(4):1471-1486.e12. doi: 10.1053/j.gastro.2020.06.010. Epub 2020 Jun 15.
2
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.线粒体酰胺氧化酶还原酶 1 基因的错义变异与肝脏疾病的保护作用。
PLoS Genet. 2020 Apr 13;16(4):e1008629. doi: 10.1371/journal.pgen.1008629. eCollection 2020 Apr.
3
Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism.使用可修饰的 SIRT1 代谢物的定制工程诱导多能干细胞生成人源脂肪肝。
Cell Metab. 2019 Aug 6;30(2):385-401.e9. doi: 10.1016/j.cmet.2019.06.017.
4
Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids.利用多能干细胞衍生类器官模拟肝脂肪变性。
Cell Metab. 2019 Aug 6;30(2):374-384.e6. doi: 10.1016/j.cmet.2019.05.007. Epub 2019 May 30.
5
Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling.肝癌的发生需要 CD44 增强的生长因子信号抑制 p53。
Cancer Cell. 2018 Jun 11;33(6):1061-1077.e6. doi: 10.1016/j.ccell.2018.05.003.
6
Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients.比较非酒精性脂肪性肝病小鼠模型和患者肝组织的基因表达谱。
Gastroenterology. 2016 Sep;151(3):513-525.e0. doi: 10.1053/j.gastro.2016.05.051. Epub 2016 Jun 16.
7
Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis.刺猬信号通路是肝脏脂质代谢的有效调节因子，并揭示了一种与脂肪变性相关的GLI编码。
Elife. 2016 May 17;5:e13308. doi: 10.7554/eLife.13308.