Mead M J, Nathanson S D, Lee M, Peterson E
J Surg Res. 1985 Apr;38(4):319-27. doi: 10.1016/0022-4804(85)90044-7.
Survival following prophylactic lymphadenectomy by hip disarticulation in mice with three B16 melanoma variants was studied. C57/BL6 mice inoculated with viable tumor cells (F1, F10, and BL6) into the left hind foot pad were randomized to wide excision (WE) of the primary tumor alone or wide excision plus prophylactic lymphadenectomy (WE plus PL) at 1-, 2-, 3-, 4-, and 5-mm primary tumor sizes (each group, N = 6). Overall survival time was improved by WE plus PL. A significant survival advantage and cure was apparent for the F1 and F10 variants with primary tumor sizes of 2 and 3 mm (F1, 2 and 3 mm, P less than 0.001; F10, 2 mm, P less than 0.006; 3 mm, P less than 0.001), but not for the BL6 variant. Prophylactic lymphadenectomy provides a therapeutic advantage in mouse melanomas of intermediate size in two of the three variants of B16.
研究了通过髋关节离断进行预防性淋巴结清扫术对三种B16黑色素瘤变体小鼠的生存影响。将接种了活肿瘤细胞（F1、F10和BL6）的C57/BL6小鼠左后足垫随机分为仅对原发性肿瘤进行广泛切除（WE）组或在原发性肿瘤大小为1、2、3、4和5毫米时进行广泛切除加预防性淋巴结清扫术（WE加PL）组（每组，N = 6）。WE加PL可提高总生存时间。对于原发性肿瘤大小为2和3毫米的F1和F10变体，有显著的生存优势和治愈效果（F1，2和3毫米，P小于0.001；F10，2毫米，P小于0.006；3毫米，P小于0.001），但对于BL6变体则没有。在B16的三种变体中的两种中，预防性淋巴结清扫术在中等大小的小鼠黑色素瘤中具有治疗优势。
