蕨菜致癌物ptaquiloside在肝细胞原代培养/DNA修复试验中的遗传毒性
Genotoxicity of ptaquiloside, a bracken carcinogen, in the hepatocyte primary culture/DNA-repair test.
作者信息
Mori H, Sugie S, Hirono I, Yamada K, Niwa H, Ojika M
出版信息
Mutat Res. 1985 May-Jun;143(1-2):75-8. doi: 10.1016/0165-7992(85)90108-3.
PMID:4000145
Abstract
The genotoxicity of ptaquiloside (PT), recently isolated from bracken fern and shown to be carcinogenic, was examined by means of the hepatocyte primary culture/DNA-repair test. PT elicited clear unscheduled DNA synthesis with a dose-response effect. The result indicates that PT is a genotoxic carcinogen.
摘要
从蕨菜中最近分离出的ptaquiloside（PT）具有致癌性，利用肝细胞原代培养/DNA修复试验对其遗传毒性进行了检测。PT引发了明显的程序外DNA合成，呈现剂量反应效应。结果表明PT是一种遗传毒性致癌物。
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