Hirono I, Ogino H, Fujimoto M, Yamada K, Yoshida Y, Ikagawa M, Okumura M
Department of Pathology, Fujita-Gakuen Health University School of Medicine, Aichi, Japan.
J Natl Cancer Inst. 1987 Nov;79(5):1143-9.
Fifteen female ACI rats initially 5 weeks old were each given a diet containing 0.027-0.08% ptaquiloside [(PT) CAS: 87625-62-5], a carcinogen in bracken, throughout the 210-day experimental period. A control group of 20 female ACI rats was given basal diet without PT. Both ileal and urinary bladder tumors developed in all rats in the experimental group. The ileal tumors were multiple and mostly developed in the distal 10 cm of the ileum. These ileal tumors were identified histologically as epithelial tumors, such as adenomas and adenocarcinomas, and also as nonepithelial malignant tumors, malignant fibrous histiocytomas. The urinary bladder tumors were transitional cell carcinomas, keratinizing squamous cell carcinomas, and sarcomas. Papillomas of the urinary bladder were found in 4 rats in the control group. These results show that, like bracken diet, PT induces tumors in both the ileum and urinary bladder.
15只最初5周龄的雌性ACI大鼠在整个210天的实验期内，每只都被给予含有0.027 - 0.08%原蕨苷[(PT)，化学物质登记号：87625 - 62 - 5，蕨菜中的一种致癌物]的饮食。20只雌性ACI大鼠的对照组被给予不含PT的基础饮食。实验组的所有大鼠都发生了回肠和膀胱肿瘤。回肠肿瘤为多发性，大多发生在回肠远端10厘米处。这些回肠肿瘤经组织学鉴定为上皮性肿瘤，如腺瘤和腺癌，也有非上皮性恶性肿瘤，即恶性纤维组织细胞瘤。膀胱肿瘤为移行细胞癌、角化性鳞状细胞癌和肉瘤。对照组有4只大鼠出现膀胱乳头状瘤。这些结果表明，与蕨菜饮食一样，原蕨苷可诱发回肠和膀胱肿瘤。
