Wang Haixia, Han Juanjuan, Kong Hui, Ma Ce, Zhang Xin-An
College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China.
College of Exercise and Health, Shanghai Sport University, Shanghai 200438, China.
Biomolecules. 2025 Feb 8;15(2):247. doi: 10.3390/biom15020247.
N6-methyladenosine (m6A) is the most prevalent internal chemical modification in eukaryotic messenger RNA (mRNA), significantly impacting its lifecycle through dynamic and reversible processes involving methyltransferase, demethylase, and binding proteins. These processes regulate mRNA stability, splicing, nuclear export, translation, and degradation. Programmed cell death (PCD), a tightly controlled process encompassing apoptosis, pyroptosis, ferroptosis, autophagy, and necroptosis, plays a crucial role in maintaining cellular homeostasis, tissue development, and function. Recently, m6A modification has emerged as a significant research area due to its role in regulating PCD and its implications in cardiovascular diseases (CVDs). In this review, we delve into the intricate relationship between various PCD types and m6A modification, emphasizing their pivotal roles in the initiation and progression of CVDs such as myocardial ischemia-reperfusion (I/R), atherosclerosis (AS), pulmonary hypertension (PH), cardiomyopathy, doxorubicin (Dox)-induced cardiotoxicity (DIC), heart failure (HF), and myocardial infarction (MI). Our findings underscore the potential of elucidating the roles of m6A and PCD in CVD to pave new pathways for prevention and treatment strategies.
N6-甲基腺苷（m6A）是真核生物信使核糖核酸（mRNA）中最普遍的内部化学修饰，通过涉及甲基转移酶、去甲基酶和结合蛋白的动态可逆过程，对其生命周期产生重大影响。这些过程调节mRNA的稳定性、剪接、核输出、翻译和降解。程序性细胞死亡（PCD）是一个严格控制的过程，包括凋亡、焦亡、铁死亡、自噬和坏死性凋亡，在维持细胞稳态、组织发育和功能方面发挥着关键作用。最近，m6A修饰因其在调节PCD中的作用及其在心血管疾病（CVD）中的意义而成为一个重要的研究领域。在这篇综述中，我们深入探讨了各种PCD类型与m6A修饰之间的复杂关系，强调它们在诸如心肌缺血再灌注（I/R）、动脉粥样硬化（AS）、肺动脉高压（PH）、心肌病、阿霉素（Dox）诱导的心脏毒性（DIC）、心力衰竭（HF）和心肌梗死（MI）等CVD的发生和发展中的关键作用。我们的研究结果强调了阐明m6A和PCD在CVD中的作用为预防和治疗策略开辟新途径的潜力。
