Bickle Q D, Andrews B J
Parasitology. 1985 Apr;90 ( Pt 2):325-38. doi: 10.1017/s0031182000051027.
A single dose of Ro 11-3128 was found to be 98-100% effective against Schistosoma mansoni infections at intervals of 3 h to 15 days following infection, and apparently killed the schistosomula stages soon after administration, thus allowing an assessment of the immunizing potential of progressive larval stages. Following infection with 500 unirradiated cercariae, optimum resistance was manifest by groups drug-treated at 48-96 h (60-75%). Significantly lower levels of resistance occurred with early (3 h) or later (6-15 day) treatments. Superimposition of an infection treated at 15 days on a prior infection which had been treated at 2 days did not reduce the level of resistance caused by the latter, indicating that the infection plus delayed treatment had not induced suppression. Thus the peak resistance manifest during the 48-96 h period may reflect optimum expression of protective antigens. Comparison of irradiated (20 krad.) with unirradiated infections showed that, when drug-terminated 24, 48 or 96 h post-infection, irradiated cercariae induced significantly less resistance than unirradiated cercariae, perhaps indicating a delayed appearance of protective antigens following radiation treatment.
单次剂量的Ro 11 - 3128在感染后3小时至15天的间隔内，对曼氏血吸虫感染的有效性达98 - 100%，给药后不久显然杀死了童虫阶段，从而可以评估渐进性幼虫阶段的免疫潜力。在用500条未辐照尾蚴感染后，在48 - 96小时接受药物治疗的组表现出最佳抵抗力（60 - 75%）。早期（3小时）或晚期（6 - 15天）治疗产生的抵抗力水平显著较低。在2天接受治疗的先前感染基础上叠加15天治疗的感染，并未降低后者引起的抵抗力水平，这表明感染加延迟治疗并未诱导抑制作用。因此，在48 - 96小时期间表现出的峰值抵抗力可能反映了保护性抗原的最佳表达。辐照（20千拉德）感染与未辐照感染的比较表明，感染后24、48或96小时用药物终止时，辐照尾蚴诱导的抵抗力明显低于未辐照尾蚴，这可能表明辐照处理后保护性抗原出现延迟。
