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大型语言模型在抗生素处方和抗菌药物管理方面的优势与局限性

Advantages and limitations of large language models for antibiotic prescribing and antimicrobial stewardship.

作者信息

Giacobbe Daniele Roberto, Marelli Cristina, La Manna Bianca, Padua Donatella, Malva Alberto, Guastavino Sabrina, Signori Alessio, Mora Sara, Rosso Nicola, Campi Cristina, Piana Michele, Murgia Ylenia, Giacomini Mauro, Bassetti Matteo

机构信息

Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

UO Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

出版信息

NPJ Antimicrob Resist. 2025 Feb 27;3(1):14. doi: 10.1038/s44259-025-00084-5.

DOI:10.1038/s44259-025-00084-5
PMID:40016394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11868396/
Abstract

Antibiotic prescribing requires balancing optimal treatment for patients with reducing antimicrobial resistance. There is a lack of standardization in research on using large language models (LLMs) for supporting antibiotic prescribing, necessitating more efforts to identify biases and misinformation in their outputs. Educating future medical professionals on these aspects is crucial for ensuring the proper use of LLMs for supporting antibiotic prescribing, providing a deeper understanding of their strengths and limitations.

摘要

抗生素处方需要在为患者提供最佳治疗与降低抗菌药物耐药性之间取得平衡。在使用大语言模型(LLMs)支持抗生素处方的研究方面缺乏标准化,因此需要付出更多努力来识别其输出中的偏差和错误信息。就这些方面对未来医学专业人员进行教育,对于确保正确使用大语言模型支持抗生素处方、更深入了解其优势和局限性至关重要。

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本文引用的文献

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Antimicrobial stewardship: a definition with a One Health perspective.抗菌药物管理:从“同一健康”视角给出的定义
NPJ Antimicrob Resist. 2024 May 2;2(1):15. doi: 10.1038/s44259-024-00031-w.
2
Toward expert-level medical question answering with large language models.迈向使用大语言模型实现专家级医学问答
Nat Med. 2025 Mar;31(3):943-950. doi: 10.1038/s41591-024-03423-7. Epub 2025 Jan 8.
3
Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050.全球细菌对抗菌药物耐药性的负担 1990-2021:一项系统分析及对 2050 年的预测。
Lancet. 2024 Sep 28;404(10459):1199-1226. doi: 10.1016/S0140-6736(24)01867-1. Epub 2024 Sep 16.
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Large Language Models, scientific knowledge and factuality: A framework to streamline human expert evaluation.大语言模型、科学知识与真实性:简化人类专家评估的框架。
J Biomed Inform. 2024 Oct;158:104724. doi: 10.1016/j.jbi.2024.104724. Epub 2024 Sep 12.
5
Assessing ChatGPT's theoretical knowledge and prescriptive accuracy in bacterial infections: a comparative study with infectious diseases residents and specialists.评估ChatGPT在细菌感染方面的理论知识和诊断准确性:与传染病住院医师和专科医生的比较研究。
Infection. 2024 Jul 12. doi: 10.1007/s15010-024-02350-6.
6
A practice-based approach to teaching antimicrobial therapy using artificial intelligence and gamified learning.一种基于实践的方法,利用人工智能和游戏化学习来教授抗菌治疗。
JAC Antimicrob Resist. 2024 Jul 6;6(4):dlae099. doi: 10.1093/jacamr/dlae099. eCollection 2024 Aug.
7
Exploring the capacities of ChatGPT: A comprehensive evaluation of its accuracy and repeatability in addressing helicobacter pylori-related queries.探索 ChatGPT 的能力:评估其在处理幽门螺杆菌相关查询时的准确性和可重复性。
Helicobacter. 2024 May-Jun;29(3):e13078. doi: 10.1111/hel.13078.
8
Towards the automatic calculation of the EQUAL Candida Score: Extraction of CVC-related information from EMRs of critically ill patients with candidemia in Intensive Care Units.迈向自动计算 EQUAL 念珠菌评分:从 ICU 中患有念珠菌血症的危重症患者的电子病历中提取与 CVC 相关的信息。
J Biomed Inform. 2024 Aug;156:104667. doi: 10.1016/j.jbi.2024.104667. Epub 2024 Jun 5.
9
Protocol for the development of the Chatbot Assessment Reporting Tool (CHART) for clinical advice.用于临床咨询的 Chatbot 评估报告工具 (CHART) 的开发方案。
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iScience. 2024 Apr 23;27(5):109713. doi: 10.1016/j.isci.2024.109713. eCollection 2024 May 17.