Zheng Xianping, Song Ling, Cao Ce, Sun Shoutian
Intensive Care Unit, Zibo Central Hospital, Zibo, 255024, China.
Department of Emergency, Zibo Central Hospital, No. 54 Gongqingtuan Road, Zhangdian District, Zibo, 255024, China.
Eur J Med Res. 2025 Feb 27;30(1):140. doi: 10.1186/s40001-025-02382-0.
Prostate cancer is an important health concern affecting men. Circular RNAs (circRNAs) play an important molecular biological role in regulating gene expression due to their unique structure. Studies have revealed the involvement of circRNAs in many human diseases. In prostate cancer, circRNAs can act as oncogenes or tumour suppressor genes and affect cancer cell proliferation, invasion, resistance to chemotherapy and, consequently, disease progression. Accordingly, prostate cancer-related circRNAs are expected to serve as new targets in early clinical diagnosis and targeted therapy, but the various roles of circRNAs in prostate cancer have not been fully elucidated. This article reviews the molecular pathological roles of circRNA in prostate cancer and explores its prospects as a translational medicine in clinical treatment and prognostic evaluation.
前列腺癌是影响男性健康的一个重要问题。环状RNA（circRNAs）由于其独特的结构，在调节基因表达中发挥着重要的分子生物学作用。研究表明，circRNAs参与了许多人类疾病。在前列腺癌中，circRNAs可以作为癌基因或肿瘤抑制基因，影响癌细胞的增殖、侵袭、化疗耐药性，进而影响疾病进展。因此，与前列腺癌相关的circRNAs有望成为早期临床诊断和靶向治疗的新靶点，但circRNAs在前列腺癌中的各种作用尚未完全阐明。本文综述了circRNA在前列腺癌中的分子病理作用，并探讨其在临床治疗和预后评估中作为转化医学的前景。
