Machlab Salvador, Lorenzo-Zúñiga Vicente, Pantaleon Miguel Angel, Sábado Fernando, Arieira Cátia, Pérez Arellano Elena, Cotter José, Carral David, Turbí Disla Carmen, Gorjão Ricardo, Esteban Jose Miguel, Rodriguez Sarbelio
Gastroenterology, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Sabadell, Spain.
Gastroenterology, Hospital HM Sant Jordi, Barcelona, Spain.
Endosc Int Open. 2025 Feb 26;13:a25259938. doi: 10.1055/a-2525-9938. eCollection 2025.
Clinical trials and real-world studies show a 1L polyethene glycol and ascorbic acid solution (1L PEG-ASC) to be an effective and safe bowel preparation for colonoscopy in the general population. Here, the effectiveness and safety of 1L PEG-ASC were evaluated in patients aged 80 years or older in a real-world setting.
A post-hoc analysis of an observational, multicenter, retrospective study assessed the effectiveness and safety of 1L PEG-ASC on outpatients aged ≥ 80 years old undergoing colonoscopy at eight centers in Spain and Portugal. Cleansing quality was assessed using the Boston Bowel Preparation Scale, with overall scores ≥ 6 and all segmental scores ≥ 2 considered adequate colon cleansing, and overall scores ≥ 8 or 3 in the right colon considered high-quality cleansing. Cecal intubation rate, withdrawal time, polyp and adenoma detection rates (ADR), and adverse events (AEs) were also monitored.
Data were analyzed from 423 patients aged ≥ 80 years; mean age 83.5 years (±3.2) and 49.2% males. The adequate colon cleansing success rate was 88.9%, with high-quality cleansing of the overall and right colon achieved in 54.1% and 46.1% of patients, respectively. Colonoscopy was complete in 94.1% of cases and the ADR was 51.3%. At least one AE was experienced by 4.5% of participants, the most frequent being mild dehydration (2.8%) and nausea (1.2%).
This post-hoc analysis confirms 1L PEG-ASC to be an effective and safe bowel cleansing preparation for patients aged 80 years or older in a real-world setting.
临床试验和真实世界研究表明，1升聚乙二醇和抗坏血酸溶液（1L PEG - ASC）是普通人群结肠镜检查有效的肠道准备方案。在此，我们在真实世界环境中评估了1L PEG - ASC在80岁及以上患者中的有效性和安全性。
一项观察性、多中心、回顾性研究的事后分析评估了1L PEG - ASC对西班牙和葡萄牙八个中心年龄≥80岁接受结肠镜检查的门诊患者的有效性和安全性。使用波士顿肠道准备量表评估肠道清洁质量，总分≥6且所有节段分数≥2被认为肠道清洁充分，总分≥8或右半结肠分数≥3被认为是高质量清洁。还监测了盲肠插管率、退镜时间、息肉和腺瘤检出率（ADR）以及不良事件（AE）。
分析了423例年龄≥80岁患者的数据；平均年龄83.5岁（±3.2），男性占49.2%。肠道清洁充分成功率为88.9%，分别有54.1%和46.1%的患者实现了全结肠和右半结肠的高质量清洁。94.1%的病例结肠镜检查完成，ADR为51.3%。4.5%的参与者经历了至少一次AE，最常见的是轻度脱水（2.8%）和恶心（1.2%）。
这项事后分析证实，在真实世界环境中，1L PEG - ASC是80岁及以上患者有效且安全的肠道清洁准备方案。
