Butch Christopher M, Hillesheim Patrick C, Mirjafari Arsalan
Department of Chemistry, State University of New York at Oswego, Oswego, New York 13126, United States.
Department of Chemistry and Physics, Ave Maria University, Ave Maria, Florida 34142, United States.
Precis Chem. 2024 Nov 21;3(2):105-107. doi: 10.1021/prechem.4c00088. eCollection 2025 Feb 24.
In this Comment, we suggest salt metathesis (or ion exchange) as an ultimate click reaction, extending click chemistry principles beyond covalent bonds to ionic interactions. These universal and robust reactions, which nature utilizes in marine organisms' biomineralization processes, proceed spontaneously under mild conditions with minimal waste, embodying the core principles of click philosophy. This perspective expands the traditional scope of click chemistry and opens new opportunities in synthetic accessibility across organic, inorganic, and materials science spaces.
在本评论中，我们提出盐复分解反应（或离子交换反应）是一种终极点击反应，将点击化学原理从共价键扩展到离子相互作用。这些普遍且稳健的反应，是自然界在海洋生物的生物矿化过程中所利用的，在温和条件下自发进行且产生的废物最少，体现了点击理念的核心原则。这一观点拓展了点击化学的传统范畴，并在有机、无机和材料科学领域的合成可达性方面开辟了新机遇。
