Villa Roberto Edoardo, Azimonti Giovanna, Bonos Eleftherios, Christensen Henrik, Durjava Mojca, Dusemund Birgit, Gehring Ronette, Glandorf Boet, Kouba Maryline, López-Alonso Marta, Marcon Francesca, Nebbia Carlo, Pechová Alena, Prieto-Maradona Miguel, Röhe Ilen, Theodoridou Katerina, Anguita Montserrat, Bozzi Cionci Nicole, Innocenti Matteo L, Woutersen Ruud, Tarrés-Call Jordi
EFSA J. 2025 Feb 27;23(2):e9258. doi: 10.2903/j.efsa.2025.9258. eCollection 2025 Feb.
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-arginine produced with KCCM 80387 as a nutritional feed additive for all animal species (category: nutritional additive; functional group: amino acids, their salts and analogues; and category: sensory additives; functional group: flavouring compounds). The production strain KCCM 80387 is a genetically modified strain and raises no safety concerns. The FEEDAP Panel concluded that the additive does not pose any safety concern with regard to the production strain. The use of l-arginine produced by fermentation with KCCM 80387 in feed as nutritional additive or as flavouring compound is safe for the target species. The FEEDAP Panel has concerns on the use of l-arginine in water for drinking. The use of l-arginine produced by fermentation with KCCM 80387 in animal nutrition is considered safe for the consumers and for the environment. As regards the safety for the user, l-arginine produced with KCCM 80387 is not irritant to skin, and not a dermal sensitiser but is irritant to the eyes and respiratory tract. The additive l-arginine produced by fermentation with KCCM 80387 is regarded as an efficacious source of the essential amino acid l-arginine for non-ruminant nutrition. For the supplemental l-arginine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen. l-Arginine is also considered efficacious when used as a flavouring compound in animal nutrition.
应欧盟委员会的要求，欧洲食品安全局被要求就以KCCM 80387生产的L-精氨酸作为所有动物物种的营养饲料添加剂的安全性和有效性提供科学意见（类别：营养添加剂；功能组：氨基酸及其盐类和类似物；以及类别：感官添加剂；功能组：调味化合物）。生产菌株KCCM 80387是一种转基因菌株，不存在安全问题。饲料添加剂和产品授权小组得出结论，该添加剂在生产菌株方面不存在任何安全问题。在饲料中使用由KCCM 80387发酵生产的L-精氨酸作为营养添加剂或调味化合物对目标物种是安全的。饲料添加剂和产品授权小组对在饮用水中使用L-精氨酸表示关切。在动物营养中使用由KCCM 80387发酵生产的L-精氨酸被认为对消费者和环境是安全的。关于对使用者的安全性，用KCCM 80387生产的L-精氨酸对皮肤无刺激性，不是皮肤致敏剂，但对眼睛和呼吸道有刺激性。由KCCM 80387发酵生产的添加剂L-精氨酸被认为是反刍动物营养中必需氨基酸L-精氨酸的有效来源。为使补充的L-精氨酸在反刍动物中与在非反刍动物物种中一样有效，需要防止其在瘤胃中降解。L-精氨酸在动物营养中用作调味化合物时也被认为是有效的。
