Murakoshi Kazuteru, Mori Hirotake, Prasertbun Rapeepun, Valenti Simon, Krokva Daria, Remez Dmytro, Mahittikorn Aongart, Hadano Yoshiro, Naito Toshio
Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.
Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Sci Rep. 2025 Feb 28;15(1):7228. doi: 10.1038/s41598-025-91499-7.
Hepatitis A infection is an acute hepatitis disease transmitted through contaminated water, food, and sexual contact, especially among men who have sex with men (MSM). This retrospective cohort study analyzed trends in hepatitis A infection in Japan, France, and Thailand from 2007 to 2021 to investigate varied epidemic trends including the MSM pandemic and the COVID-19 pandemic under different public health conditions. We analyzed annual and monthly number of cases using the national surveillance databases of Japan, France, and Thailand. We statistically evaluated the decrease in hepatitis A after the COVID pandemic. Hepatitis A average incidence in Japan, France, and Thailand was 0.21, 1.79, and 0.75, respectively. Outbreaks were recorded in 2010, 2014, and 2018 for Japan, 2009 and 2017 for France, and 2012 and 2017 for Thailand. In 2012, a hepatitis A outbreak was recorded at an ice manufacturing factory in Thailand. In Japan, in 2014, 80.5% of cases were transmitted by contaminated seafood or water. Hepatitis A increased during 2017-2018 (324% in 2018 Japan, 489% in 2017 France, 166% in Thailand), possibly linked to the global MSM pandemic. After the COVID-19 pandemic, the cases significantly decreased in all three countries (p < 0.001). The characteristics of hepatitis A epidemic may reflect the activities of people, including high-risk groups.
甲型肝炎感染是一种通过受污染的水、食物和性接触传播的急性肝炎疾病，尤其是在男男性行为者（MSM）中。这项回顾性队列研究分析了2007年至2021年日本、法国和泰国甲型肝炎感染的趋势，以调查在不同公共卫生条件下包括男男性行为者大流行和新冠疫情在内的各种流行趋势。我们使用日本、法国和泰国的国家监测数据库分析了年度和月度病例数。我们对新冠疫情后甲型肝炎病例的减少进行了统计学评估。日本、法国和泰国的甲型肝炎平均发病率分别为0.21、1.79和0.75。日本在2010年、2014年和2018年有疫情记录，法国在2009年和2017年有疫情记录，泰国在2012年和2017年有疫情记录。2012年，泰国一家制冰厂记录了甲型肝炎疫情。在日本，2014年，80.5%的病例是通过受污染的海鲜或水传播的。甲型肝炎在2017 - 2018年期间有所增加（2018年日本增加了324%，2017年法国增加了489%，泰国增加了166%），这可能与全球男男性行为者大流行有关。新冠疫情后，这三个国家的病例数均显著下降（p < 0.001）。甲型肝炎流行的特征可能反映了包括高危人群在内的人群活动情况。
