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预训练卷积神经网络从语音样本的频谱图图像中识别帕金森病。

Pre-trained convolutional neural networks identify Parkinson's disease from spectrogram images of voice samples.

作者信息

Rahmatallah Yasir, Kemp Aaron S, Iyer Anu, Pillai Lakshmi, Larson-Prior Linda J, Virmani Tuhin, Prior Fred

机构信息

Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, 72205, USA.

Georgia Institute of Technology, Atlanta, 30332, USA.

出版信息

Sci Rep. 2025 Mar 1;15(1):7337. doi: 10.1038/s41598-025-92105-6.

DOI:10.1038/s41598-025-92105-6
PMID:40025201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11873116/
Abstract

Machine learning approaches including deep learning models have shown promising performance in the automatic detection of Parkinson's disease. These approaches rely on different types of data with voice recordings being the most used due to the convenient and non-invasive nature of data acquisition. Our group has successfully developed a novel approach that uses convolutional neural network with transfer learning to analyze spectrogram images of the sustained vowel /a/ to identify people with Parkinson's disease. We tested this approach by collecting a dataset of voice recordings via analog telephone lines, which support limited bandwidth. The convolutional neural network with transfer learning approach showed superior performance against conventional machine learning methods that collapse measurements across time to generate feature vectors. This study builds upon our prior results and presents two novel contributions: First, we tested the performance of our approach on a larger voice dataset recorded using smartphones with wide bandwidth. Our results show comparable performance between two datasets generated using different recording platforms despite the differences in most important features resulting from the limited bandwidth of analog telephonic lines. Second, we compared the classification performance achieved using linear-scale and mel-scale spectrogram images and showed a small but statistically significant gain using mel-scale spectrograms.

摘要

包括深度学习模型在内的机器学习方法在帕金森病的自动检测中已显示出有前景的性能。这些方法依赖于不同类型的数据,由于数据采集方便且无创,语音记录是最常用的。我们团队成功开发了一种新颖的方法,该方法使用带有迁移学习的卷积神经网络来分析持续元音/a/的频谱图图像,以识别帕金森病患者。我们通过经由支持有限带宽的模拟电话线收集语音记录数据集来测试这种方法。与将跨时间的测量值合并以生成特征向量的传统机器学习方法相比,带有迁移学习的卷积神经网络方法表现出卓越的性能。本研究基于我们之前的结果,并提出了两个新的贡献:第一,我们在使用具有宽带宽的智能手机录制的更大语音数据集上测试了我们方法的性能。我们的结果表明,尽管模拟电话线的有限带宽导致了最重要特征存在差异,但使用不同录制平台生成的两个数据集之间的性能相当。第二,我们比较了使用线性尺度和梅尔尺度频谱图图像实现的分类性能,并表明使用梅尔尺度频谱图有虽小但在统计上显著的提升。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b0f/11873116/d0f74db7c73d/41598_2025_92105_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b0f/11873116/d0f74db7c73d/41598_2025_92105_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b0f/11873116/d0f74db7c73d/41598_2025_92105_Fig3_HTML.jpg

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本文引用的文献

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Sensors (Basel). 2024 Jul 17;24(14):4625. doi: 10.3390/s24144625.
2
Leveraging Deep Learning for Fine-Grained Categorization of Parkinson's Disease Progression Levels through Analysis of Vocal Acoustic Patterns.通过分析语音声学模式,利用深度学习对帕金森病进展水平进行细粒度分类。
Bioengineering (Basel). 2024 Mar 21;11(3):295. doi: 10.3390/bioengineering11030295.
3
A novel hybrid model integrating MFCC and acoustic parameters for voice disorder detection.
一种融合 MFCC 和声学参数的新型混合模型用于语音障碍检测。
Sci Rep. 2023 Dec 20;13(1):22719. doi: 10.1038/s41598-023-49869-6.
4
A machine learning method to process voice samples for identification of Parkinson's disease.一种用于处理语音样本以识别帕金森病的机器学习方法。
Sci Rep. 2023 Nov 23;13(1):20615. doi: 10.1038/s41598-023-47568-w.
5
CNN-Based Identification of Parkinson's Disease from Continuous Speech in Noisy Environments.基于卷积神经网络在噪声环境下从连续语音中识别帕金森病
Bioengineering (Basel). 2023 Apr 26;10(5):531. doi: 10.3390/bioengineering10050531.
6
Clinical Diagnostic Accuracy of Parkinson's Disease: Where Do We Stand?帕金森病的临床诊断准确性:我们处于何种水平?
Mov Disord. 2023 Apr;38(4):558-566. doi: 10.1002/mds.29317. Epub 2023 Jan 5.
7
Feasibility of telemedicine research visits in people with Parkinson's disease residing in medically underserved areas.针对居住在医疗服务不足地区的帕金森病患者开展远程医疗研究访视的可行性。
J Clin Transl Sci. 2022 Sep 12;6(1):e133. doi: 10.1017/cts.2022.459. eCollection 2022.
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Classification of Parkinson's disease from smartphone recording data using time-frequency analysis and convolutional neural network.基于时频分析和卷积神经网络的帕金森病智能手机记录数据分类
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External validation: a simulation study to compare cross-validation versus holdout or external testing to assess the performance of clinical prediction models using PET data from DLBCL patients.外部验证:一项模拟研究,比较交叉验证与留出法或外部测试,以使用弥漫性大B细胞淋巴瘤(DLBCL)患者的PET数据评估临床预测模型的性能。
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