Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, SAR, 999078, China.
School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 3083, Australia.
Small. 2021 Oct;17(43):e2100314. doi: 10.1002/smll.202100314. Epub 2021 May 21.
Nanomedicine integrates different functional materials to realize the customization of carriers, aiming at increasing the cancer therapeutic efficacy and reducing the off-target toxicity. However, efforts on developing new drug carriers that combine precise diagnosis and accurate treatment have met challenges of uneasy synthesis, poor stability, difficult metabolism, and high cytotoxicity. Metal-phenolic networks (MPNs), making use of the coordination between phenolic ligands and metal ions, have emerged as promising candidates for nanomedicine, most notably through the service as multifunctional theranostic nanoplatforms. MPNs present unique properties, such as rapid preparation, negligible cytotoxicity, and pH responsiveness. Additionally, MPNs can be further modified and functionalized to meet specific application requirements. Here, the classification of polyphenols is first summarized, followed by the introduction of the properties and preparation strategies of MPNs. Then, their recent advances in biomedical sciences including bioimaging and anti-tumor therapies are highlighted. Finally, the main limitations, challenges, and outlooks regarding MPNs are raised and discussed.
纳米医学将不同功能材料整合到一起，实现载体的定制化，旨在提高癌症治疗效果，降低脱靶毒性。然而，开发集精准诊断与精确治疗于一体的新型药物载体，在合成不易、稳定性差、代谢困难和细胞毒性高方面面临挑战。金属-酚网络（MPNs）利用酚配体与金属离子之间的配位作用，作为有前途的纳米医学候选物出现，尤其是作为多功能治疗诊断纳米平台。MPNs 具有快速制备、细胞毒性可忽略不计和 pH 响应等独特性质。此外，MPNs 可以进一步修饰和功能化，以满足特定的应用需求。在这里，首先总结了多酚的分类，然后介绍了 MPNs 的性质和制备策略。接着，重点介绍了它们在生物医学科学中的最新进展，包括生物成像和抗肿瘤治疗。最后，提出并讨论了 MPNs 的主要局限性、挑战和展望。
