通过审视电子显微镜图像来发现细胞中的蛋白质。
On interrogating electron microscopy images to discover proteins in the cell.
作者信息
Carazo Jose Maria
机构信息
Spanish National Center for Biotechnology, CNB-CSIC, Darwin 3, 28049 Madrid, Spain.
出版信息
IUCrJ. 2025 Mar 1;12(Pt 2):139-140. doi: 10.1107/S2052252525001861.
Abstract
Interrogating individual two-dimensional (2D) cryo-EM images for the presence of defined three-dimensional (3D) structures that correspond to previously known (or predicted) macromolecular complexes is very challenging, but offers attractive opportunities for the analysis of large numbers of specimens. The work of Zhang et al. [(2025), IUCrJ, 12, 155-176] represents a significant step forward towards this goal.
摘要
在二维（2D）冷冻电镜图像中探寻与先前已知（或预测）的大分子复合物相对应的特定三维（3D）结构极具挑战性，但为大量样本的分析提供了诱人的机会。张等人[（2025年），《IUCrJ》，12，155 - 176]的工作朝着这一目标迈出了重要一步。
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