Center for Biomolecular Magnetic Resonance (BMRZ), Institute for Organic Chemistry, Max-von-Laue-Str. 7, 60438 Frankfurt/M., Germany; Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford OX4 2JY, UK.
Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford OX4 2JY, UK.
Structure. 2024 Oct 3;32(10):1563-1580. doi: 10.1016/j.str.2024.08.014. Epub 2024 Sep 17.
Instruct-ERIC, "the European Research Infrastructure Consortium for Structural biology research," is a pan-European distributed research infrastructure making high-end technologies and methods in structural biology available to users. Here, we describe the current state-of-the-art of integrated structural biology and discuss potential future scientific developments as an impulse for the scientific community, many of which are located in Europe and are associated with Instruct. We reflect on where to focus scientific and technological initiatives within the distributed Instruct research infrastructure. This review does not intend to make recommendations on funding requirements or initiatives directly, neither at the national nor the European level. However, it addresses future challenges and opportunities for the field, and foresees the need for a stronger coordination within the European and international research field of integrated structural biology to be able to respond timely to thematic topics that are often prioritized by calls for funding addressing societal needs.
Instruct-ERIC，即“结构生物学研究的欧洲研究基础设施联合会”，是一个泛欧分布式研究基础设施，为用户提供结构生物学领域的高端技术和方法。在这里，我们描述了集成结构生物学的最新现状，并讨论了潜在的未来科学发展，为科学界提供了灵感，其中许多发展都位于欧洲，并且与 Instruct 有关。我们思考了在分布式 Instruct 研究基础设施中应该将科学和技术举措集中在哪些方面。本综述并非旨在直接针对国家或欧洲层面的资金需求或举措提出建议。然而，它涉及该领域的未来挑战和机遇，并预见需要在欧洲和国际综合结构生物学研究领域内进行更紧密的协调，以便能够及时应对通常由解决社会需求的资金呼吁优先考虑的主题。
