Albuquerque Camila F B, de Souza Dayenne A A, Figueiredo Pablo Luis B, Rocha Cláudia Quintino, Maia José Guilherme S, Kato Massuo J, Chisté Renan Campos, da Silva Joyce Kelly R
Programa de Pós-Graduação em Biotecnologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA 66075-110, Brazil.
Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal do Pará, Belém, PA 66075-110, Brazil.
ACS Omega. 2025 Feb 13;10(7):7371-7380. doi: 10.1021/acsomega.4c11241. eCollection 2025 Feb 25.
, also known as cutite, is an Amazonian fruit distributed in the western regions of North Brazil. Its fruits are rich in phenolic compounds, such as gallic acid (GA) and quercetin (Q), making it an excellent ingredient for cosmetic applications due to its high antioxidant activity and stability. A study optimized the extraction of GA and Q using hydroalcoholic ultrasound-assisted extracts by a central composite design, focusing on three independent variables: water-ethanol percentage (%HO; v/v), fruit-solvent ratio (FSR; w/v), and time (; min). Response surface methodology was used to identify the optimal conditions for maximizing gallic acid and quercetin content. Results showed antioxidant activity ranged from 1365.15 to 265.50 mg TE/mL and total phenolic compounds from 4293.7 to 897.04 mg GAE/L. A direct correlation between %HO and FSR in the quercetin content response was observed. On the other hand, there was an inverse correlation between the FSR and the extraction of gallic acid, with a significance level of 90% ( < 0.1). The optimization of cutite hydroalcoholic extracts resulted in 10.22 ± 0.6 mg/L and 0.75 ± 0.25 mg/L for gallic acid and quercetin, respectively. Moreover, the optimized extract displayed a sun protection factor of 54, indicating its potential in cosmetic formulations and sunscreen products.
[水果名称]，也被称为库蒂特，是一种分布在巴西北部西部地区的亚马逊水果。其果实富含酚类化合物，如没食子酸（GA）和槲皮素（Q），由于其高抗氧化活性和稳定性，使其成为化妆品应用的优良成分。一项研究通过中心复合设计优化了使用水醇超声辅助提取物提取GA和Q的方法，重点关注三个独立变量：水 - 乙醇百分比（%HO；v/v）、水果 - 溶剂比（FSR；w/v）和时间（；分钟）。采用响应面法确定使没食子酸和槲皮素含量最大化的最佳条件。结果表明抗氧化活性范围为1365.15至265.50 mg TE/mL，总酚类化合物范围为4293.7至897.04 mg GAE/L。观察到槲皮素含量响应中%HO与FSR之间存在直接相关性。另一方面，FSR与没食子酸提取之间存在负相关，显著性水平为90%（<0.1）。库蒂特水醇提取物的优化结果是没食子酸和槲皮素分别为10.22±0.6 mg/L和0.75±0.25 mg/L。此外，优化后的提取物显示出54的防晒系数，表明其在化妆品配方和防晒产品中的潜力。
