Riesenfeld A
Acta Anat (Basel). 1985;122(1):18-24. doi: 10.1159/000145978.
Inbred Buffalo and Fisher rats were submitted to daily treatment with alcohol and nicotine for a period of 6 months. Alcohol treatment was pre- and postnatal, nicotine treatment postnatal only. All parameters of bone length and weight were depressed in both experiments in spite of the continuous growth of the rats. Although the level of depression was greater in some areas than in others, a clear target area applicable to both sexes and strains could not be found. Fisher and Buffalo females tolerated nicotine better than males. Buffalo rats showed a greater tolerance to alcohol than Fisher rats, and males tolerated alcohol better than females. This was particularly evident in pregnant rats: whereas all alcohol-treated Fisher embryos were stillborn, some of their Buffalo counterparts survived. This is most likely due to the lesser bone robusticity of Fisher over Buffalo rats and resorption of the fetal bones in Fisher embryos resulting from the decalcifying effect of alcohol.
将近交系布法罗大鼠和费希尔大鼠在6个月的时间里每天给予酒精和尼古丁处理。酒精处理在产前和产后进行，尼古丁处理仅在产后进行。尽管大鼠持续生长，但在两个实验中，所有骨长度和重量参数均降低。虽然某些区域的降低程度比其他区域更大，但未发现适用于两性和品系的明确目标区域。费希尔和布法罗雌性大鼠比雄性大鼠对尼古丁的耐受性更好。布法罗大鼠比费希尔大鼠对酒精的耐受性更强，雄性大鼠比雌性大鼠对酒精的耐受性更好。这在怀孕大鼠中尤为明显：所有经酒精处理的费希尔胚胎均为死产，而它们的一些布法罗对应胚胎存活下来。这很可能是由于费希尔大鼠的骨骼强度低于布法罗大鼠，以及酒精的脱钙作用导致费希尔胚胎中的胎儿骨骼吸收。
