Dorchy H, Bourdoux P, Lemiere B
Acta Paediatr Scand. 1985 May;74(3):386-9. doi: 10.1111/j.1651-2227.1985.tb10989.x.
The serum levels of thyroid hormones and thyroid stimulating hormone were compared in 64 type I diabetic children and adolescents without ketosis and in 28 age matched normal subjects. Only T3 levels were significantly different in the diabetic patients (2.38 +/- 0.41 nmol/l) than in controls (2.64 +/- 0.52 nmol/l) (p less than 0.01) confirming the existence of the 'low T3 syndrome' in diabetic children. A negative correlation was found between T3 and blood glucose as well as glycosylated haemoglobin suggesting that short-term hyperglycaemia could regulate T3 concentration. Thyroid function was not different in diabetic children with or without thyroid antibodies. We conclude that serum T3 level is influenced by the degree of metabolic control and that thyroid function in diabetic children should be assessed by the measurement of the serum concentration of T4, FT4 and TSH.
对64名无酮症的I型糖尿病儿童及青少年以及28名年龄匹配的正常受试者的甲状腺激素和促甲状腺激素血清水平进行了比较。糖尿病患者的仅T3水平（2.38±0.41nmol/l）与对照组（2.64±0.52nmol/l）相比有显著差异（p<0.01），证实糖尿病儿童存在“低T3综合征”。发现T3与血糖以及糖化血红蛋白之间呈负相关，提示短期高血糖可能调节T3浓度。有或无甲状腺抗体的糖尿病儿童的甲状腺功能无差异。我们得出结论，血清T3水平受代谢控制程度的影响，糖尿病儿童的甲状腺功能应通过测定血清T4、FT4和TSH浓度来评估。
