Kheradmandi Rasoul, Zamani Sepehr, Farahani Mohammad Kamalabadi, Ehterami Arian, Salehi Majid
Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Regenerative Medicine Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
Biopolymers. 2025 Mar;116(2):e70007. doi: 10.1002/bip.70007.
This comprehensive review explores the potential of plant- and biopolymeric-based antibacterials as innovative therapeutic agents for infectious skin wound healing. By researching the antibacterial properties of various plants, the review highlights their application in skin tissue engineering. Beyond reviewing antibacterial plant extracts, the article delves into the limitations these natural compounds face, such as hydrophilicity, drug release rates, cell attachment, and scaffold stability when integrated into tissue engineering constructs. The review also emphasizes the role of biopolymeric materials, hydrogel optimization, and crosslinkers to improve scaffold performance. This review provides a roadmap for future research by addressing critical factors in scaffold construction. In the end, it aims to guide the development of more effective wound dressings and tissue scaffolds, combining the natural power of plants with advanced biopolymeric materials for enhanced wound healing therapies.
这篇综述探讨了基于植物和生物聚合物的抗菌剂作为感染性皮肤伤口愈合创新治疗剂的潜力。通过研究各种植物的抗菌特性，该综述突出了它们在皮肤组织工程中的应用。除了回顾抗菌植物提取物外，本文还深入探讨了这些天然化合物面临的局限性，例如亲水性、药物释放速率、细胞附着以及整合到组织工程构建体时的支架稳定性。该综述还强调了生物聚合物材料、水凝胶优化和交联剂在改善支架性能方面的作用。通过解决支架构建中的关键因素，本综述为未来的研究提供了路线图。最后，它旨在指导开发更有效的伤口敷料和组织支架，将植物的天然力量与先进的生物聚合物材料相结合，以增强伤口愈合治疗效果。
