Department of Mechanical Engineering, Anna University, Chennai, Tamil Nadu, India.
Department of Chemistry, Thiagarajar College, Madurai 625009 Tamil Nadu, India.
Biomed Mater. 2021 Apr 13;16(4). doi: 10.1088/1748-605X/abef59.
Wound healing is an urgent problem that impacts quality of life, and the need for biomaterials suitable for the treatment of skin wound healing disease is increasing annually. Innovative biomaterials and treatments for skin abrasions are being relentlessly researched and established in order to improve treatment efficacy. Here, we describe a novel electrospun polymeric nanofibrous scaffold enriched with pharmaceutical bioactive materials extracted from(MC), which demonstrated efficient skin wound healing therapy due to its excellent human skin keratinocyte proliferation and adhesion inanalysis. Surface morphological analysis was used to reveal the nano-architectural structure of the electrospun scaffolds. The fabricated nanofibers displayed good antibacterial efficacy by creating an inhibitory zone for the pathogenic microbes studied. MC supported active healing due to the presence of pharmaceuticals associated with wound healing, as revealed by the results of gas chromatography-mass spectrometry and the prediction of activity spectra for substances (PASS) analysis. Since MC is a multi-potential therapeutic herbal plant, it was found that the linoleic acid, olelic acid, and diethyl phthalate present in the extract supported the wound healing proteins glycogen-synthase-kinase-3--protein and Protein Data Bank-1Q5K with binding energies of -4.6, -5.2, and -5.9 kcal mol, as established by the results ofanalysis. Thus, by being hydrophilic in nature, targeting wound proteins, increasing the proliferation and adhesion of keratinocytes and combating pathogens, the nanofibrous scaffolds endowed with MC extract proved to be an effective therapeutic material for skin wound dressing applications.
伤口愈合是一个紧迫的问题，影响着生活质量，每年对适合治疗皮肤伤口愈合疾病的生物材料的需求都在增加。为了提高治疗效果，人们正在不懈地研究和开发创新的生物材料和皮肤擦伤治疗方法。在这里，我们描述了一种新型的电纺聚合物纳米纤维支架，该支架富含从(MC)中提取的药物生物活性材料，由于其在人皮肤角质细胞增殖和黏附方面的优异性能，在分析中显示出有效的皮肤伤口愈合治疗效果。表面形态分析用于揭示电纺支架的纳米结构。所制备的纳米纤维通过为研究的致病微生物创造抑制区显示出良好的抗菌功效。由于 MC 中存在与伤口愈合相关的药物，因此支持积极的愈合，这一点通过气相色谱-质谱分析和物质活性光谱预测(PASS)分析的结果得到证实。由于 MC 是一种多效治疗性草药植物，因此发现提取物中的亚油酸、油酸和邻苯二甲酸二乙酯支持伤口愈合蛋白糖原合成酶激酶-3-蛋白和蛋白质数据库-1Q5K，其结合能分别为-4.6、-5.2 和-5.9 kcal mol，这是通过分析结果确定的。因此，由于具有亲水性，靶向伤口蛋白，增加角质细胞的增殖和黏附，以及对抗病原体，因此具有 MC 提取物的纳米纤维支架被证明是一种有效的皮肤伤口敷料应用治疗材料。
