铁死亡相关基因作为三阴性乳腺癌生存和免疫治疗的预后标志物：公共数据库和单一机构分析
Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution.
作者信息
Xie Yizhao, Tao Zhonghua, Wang Biyun, Zhao Yannan, Chen Xinyu, Li Bin, Wang Jinyan, Chen Guangliang, Hu Xichun
机构信息
Department of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
出版信息
Ther Adv Med Oncol. 2025 Feb 28;17:17588359251322291. doi: 10.1177/17588359251322291. eCollection 2025.
BACKGROUND
Ferroptosis plays a vital role in cancer development and treatment. The relationship between ferroptosis-related genes and breast cancer prognosis, as well as immunotherapy outcomes, remains unknown.
OBJECTIVES
To evaluate the prognostic value of ferroptosis-related genes in breast cancer.
METHODS
We conducted differential expressions and prognostic analysis for ferroptosis-related genes on public databases and breast cancer patients in our center and analyzed their predictive value for immunotherapy of breast cancer patients.
RESULTS
We identified prognostic ferroptosis-related genes, constructed a nomogram, and validated key genes using patient data from our center. We also investigated ferroptosis-related genes significantly associated with immune infiltration and identified as a promising biomarker for triple-negative breast cancer immunotherapy.
CONCLUSION
Ferroptosis-related genes had potential prognostic value and predictive value for breast cancer immunotherapy.
背景
铁死亡在癌症的发生发展及治疗中起着至关重要的作用。铁死亡相关基因与乳腺癌预后以及免疫治疗结果之间的关系尚不清楚。
目的
评估铁死亡相关基因在乳腺癌中的预后价值。
方法
我们在公共数据库以及本中心的乳腺癌患者中对铁死亡相关基因进行差异表达和预后分析，并分析它们对乳腺癌患者免疫治疗的预测价值。
结果
我们鉴定出了预后性铁死亡相关基因，构建了列线图，并使用本中心的患者数据验证了关键基因。我们还研究了与免疫浸润显著相关的铁死亡相关基因，并确定其为三阴性乳腺癌免疫治疗的一个有前景的生物标志物。
结论
铁死亡相关基因对乳腺癌免疫治疗具有潜在的预后价值和预测价值。
Zotero 插件