石榴补充剂对运动诱导的肌肉损伤标志物的影响：一项系统评价和荟萃分析。
The Effects of Pomegranate Supplementation on Markers of Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis.
作者信息
Belyani Saba, Kazeminasab Fatemeh, Niazi Mahnaz, Bagheri Reza, Hesari Mahsa Mahabadi, Rosenkranz Sara K, Camera Donny M, Dutheil Fred
机构信息
Department of Human Sciences, Human Nutrition Program, The Ohio State University, Columbus, OH, United States.
Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.
出版信息
Curr Dev Nutr. 2025 Jan 28;9(2):104560. doi: 10.1016/j.cdnut.2025.104560. eCollection 2025 Feb.
BACKGROUND
Pomegranate supplementation has been shown to reduce oxidative stress and inflammation, with some evidence suggesting it may accelerate recovery from exercise-induced muscle damage (EIMD), including metabolic, mechanical, and neuromuscular recovery.
OBJECTIVES
This systematic review and meta-analysis aimed to investigate the effects of pomegranate supplementation on markers of EIMD.
METHODS
A systematic search of Scopus, PubMed, and Web of Science up to January 2024 identified studies evaluating pomegranate supplementation and exercise recovery. Studies involving athletes and nonathletes aged 18-55 were included. Weighted mean differences (WMDs) were calculated for EIMD markers. Study quality was assessed using a modified physiotherapy evidence database scale. This review was registered with the International Prospective Register of Systematic Reviews (ID: CRD42024536905).
RESULTS
Ten studies were included in the meta-analysis. Pomegranate supplementation did not significantly affect markers of metabolic recovery, including myoglobin (WMD: -1.344 ng/mL; 95% confidence interval (CI): -4.11, 1.42 ng/mL, = 0.342) and creatine kinase (WMD: -11.990 U/L; 95% CI: -28.64, 4.66 U/L, = 0.158), or neuromuscular recovery, as indicated by lactate concentrations (WMD: -0.093 mmol/L; 95% CI: -0.39, 0.21 mmol/L, = 0.546). Muscle soreness also remained unchanged (WMD: 0.999; 95% CI: -0.18, 2.17, = 0.097). However, a significant reduction in lactate dehydrogenase amounts (WMD: -21.152 U/L; 95% CI: -39.29, -3.01 U/L, = 0.022) immediately postexercise suggests a short-term protective effect against mechanical muscle damage.
CONCLUSIONS
Pomegranate supplementation does not appear to enhance overall recovery markers for EIMD but may offer short-term benefits for mechanical muscle damage. Standardizing supplementation regimens, dosages, and exercise protocols is crucial to better understand the potential benefits of pomegranate supplementation in EIMD recovery.
背景
已证明补充石榴可减轻氧化应激和炎症，有证据表明其可能加速运动诱导的肌肉损伤（EIMD）的恢复，包括代谢、机械和神经肌肉恢复。
目的
本系统评价和荟萃分析旨在研究补充石榴对EIMD标志物的影响。
方法
截至2024年1月，对Scopus、PubMed和Web of Science进行系统检索，以确定评估补充石榴与运动恢复的研究。纳入了涉及18 - 55岁运动员和非运动员的研究。计算了EIMD标志物的加权平均差（WMD）。使用改良的物理治疗证据数据库量表评估研究质量。本评价已在国际前瞻性系统评价注册库注册（注册号：CRD42024536905）。
结果
荟萃分析纳入了10项研究。补充石榴对代谢恢复标志物没有显著影响，包括肌红蛋白（WMD：-1.344 ng/mL；95%置信区间（CI）：-4.11，1.42 ng/mL，P = 0.342）和肌酸激酶（WMD：-11.990 U/L；95% CI：-28.64，4.66 U/L，P = 0.158），也未对神经肌肉恢复产生显著影响，乳酸浓度可作为神经肌肉恢复的指标（WMD：-0.093 mmol/L；95% CI：-0.39，0.21 mmol/L，P = 0.546）。肌肉酸痛也未发生变化（WMD：0.999；95% CI：-0.18，2.17，P = 0.097）。然而，运动后即刻乳酸脱氢酶含量显著降低（WMD：-21.152 U/L；95% CI：-39.29，-3.01 U/L，P = 0.022），这表明对机械性肌肉损伤有短期保护作用。
结论
补充石榴似乎并不能增强EIMD的整体恢复标志物，但可能对机械性肌肉损伤有短期益处。规范补充方案、剂量和运动方案对于更好地理解补充石榴在EIMD恢复中的潜在益处至关重要。
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