Sepkovic D W, Haley N J
Am J Public Health. 1985 Jun;75(6):663-5. doi: 10.2105/ajph.75.6.663.
Two studies were undertaken to assess the variability of cotinine concentrations in different biological fluids and to determine the most desirable fluid to use for specific experimental protocols. For protocols validating smoking cessation, plasma or urinary cotinine determinations provided the most accurate indicators of compliance. In studies where smokers switched from high yield to low yield cigarettes, plasma cotinine determinations were good indicators of smoker behavior. Correct interpretation of smoker status is dependent on the biological fluid selected for cotinine analysis.
开展了两项研究,以评估不同生物体液中可替宁浓度的变异性,并确定用于特定实验方案的最理想体液。对于验证戒烟的方案,血浆或尿液可替宁测定提供了最准确的依从性指标。在吸烟者从高焦油含量香烟转向低焦油含量香烟的研究中,血浆可替宁测定是吸烟者行为的良好指标。对吸烟者状态的正确解读取决于选择用于可替宁分析的生物体液。