Wei Bo, Liu Chang, Zhu Jie, Zou XinYu, Zhang Zhenhua
Department of Infectious Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
BMC Infect Dis. 2025 Mar 4;25(1):313. doi: 10.1186/s12879-025-10711-1.
There is limited data regarding the sources of human Pasteurella multocida infection, characteristics of infected populations, and the antibiotic resistance patterns of human strains.
Through the multi-database platforms, we conducted a comprehensive review and analysis of 482 reported cases of Pasteurella multocida from the world since from 1964 to 2023, including the sources of infection, sex and age distribution of infected individuals, and the clinical manifestations of infection in different age groups. Additionally, we evaluated the antibiotic susceptibility of different strains of the bacterium.
P. multocida infection is mainly involved in infants and the elderly population, and it is closely related to animal exposure (cats 54.1%, dogs 29%), especially cat-related infections in adults and older are significantly more common than in children (P = 0.005, P < 0.001). Infection with P. multocida can cause local redness of the skin and soft tissue (11.6%), and also progress to systemic infection, like central nervous system (14.5%), especially in children, Cardiovascular system (29.3%), respiratory system (21.4%), digestive system (12.9%), urogenital system (2.9%) and bone and joint infections (5%). In terms of treatment, first-line treatment is priority to with penicillin. However there are also resistance to Penicillins and β-lactam antibiotics (18 cases were reported), and strains derived from wounds, blood and respiratory tract are resistant to multiple antibiotics.
P. multocida primarily causes infections through cats and dogs in different age groups, leading to various clinical manifestations and outcomes. It is generally sensitive to penicillin antibiotics but exhibits varying resistance among strains of different clinical origins. Studying these aspects is crucial to raise awareness about preventing P. multocida infections and to standardize clinical treatment approaches.
关于人类多杀巴斯德菌感染的来源、感染人群特征以及人类菌株的抗生素耐药模式的数据有限。
通过多数据库平台，我们对1964年至2023年全球报告的482例多杀巴斯德菌病例进行了全面回顾和分析，包括感染源、感染个体的性别和年龄分布以及不同年龄组的感染临床表现。此外，我们评估了该细菌不同菌株的抗生素敏感性。
多杀巴斯德菌感染主要涉及婴儿和老年人群，且与动物接触密切相关（猫54.1%，狗29%），尤其是成人和老年人中与猫相关的感染明显比儿童更常见（P = 0.005，P < 0.001）。多杀巴斯德菌感染可导致皮肤和软组织局部发红（11.6%），也可进展为全身感染，如中枢神经系统感染（14.5%），尤其是儿童，心血管系统感染（29.3%）、呼吸系统感染（21.4%）、消化系统感染（12.9%）、泌尿生殖系统感染（2.9%）和骨与关节感染（5%）。在治疗方面，一线治疗优先选用青霉素。然而，也存在对青霉素和β-内酰胺类抗生素耐药的情况（报告了18例），且来自伤口、血液和呼吸道的菌株对多种抗生素耐药。
多杀巴斯德菌主要通过猫和狗在不同年龄组引起感染，导致各种临床表现和结局。它一般对青霉素类抗生素敏感，但在不同临床来源的菌株中耐药性有所不同。研究这些方面对于提高对预防多杀巴斯德菌感染的认识以及规范临床治疗方法至关重要。
