Van Der Veek Annemijn, Loukas Serafeim, Lordier Lara, de Almeida Joana Sa, Filippa Manuela, Lazeyras François, Van De Ville Dimitri, Hüppi Petra S
Division of Development and Growth, Department of Woman, Child and Adolescent, University of Geneva, Geneva, Switzerland.
Department of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.
Imaging Neurosci (Camb). 2024 Nov 18;2:1-18. doi: 10.1162/imag_a_00373. eCollection 2024 Nov 1.
Premature birth affects brain maturation, illustrated by altered brain functional connectivity at term equivalent age (TEA) and alters neurobehavioral outcome. To correct early developmental differences and improve neurological outcome, music during the neonatal intensive care unit (NICU) stay has been proposed as an auditory enrichment with modulatory effects on functional and structural brain development, but longitudinal effects of such interventions have not been studied so far. We longitudinally investigated resting-state functional connectivity (RS-FC) maturation in preterm infants (n = 43). Data-driven Independent Component Analyses (ICA) were performed on scans obtained at 33- and 40-week gestational age (GA), determining the presence of distinct resting-state networks (RSNs). Connectome analysis "accordance measure" quantitively examined the RS-FC both at 33- and 40-week GA. Further comparing the internetwork RS-FC at 33- and 40-week GA provided a circuitry of interest (COI) for significant maturational changes in which the effects on the RS-FC of a music intervention were tested. The connectome analyses resulted in a COI of RS-FC connections significantly maturing from 33 to 40 weeks GA, namely between the thalamic/brainstem and prefrontal-limbic, salience, sensorimotor, auditory, and prefrontal cortical networks; between the prefrontal-limbic and cerebellar, visual and left hemispheric precuneus networks; between the salience and visual, and cerebellar networks; and between the sensorimotor and auditory, and posterior cingulate/precuneus networks. The infants exposed to music exhibited significantly increased maturation in RS-FC between the thalamic/brainstem and salience networks, compared with controls. This study exemplifies that preterm infant RS-FC maturation is modulated through NICU music exposure, highlighting the importance of environmental enrichment for neurodevelopment in premature newborns.
早产会影响大脑成熟，这在足月等效年龄（TEA）时大脑功能连接的改变中得到体现，并且会改变神经行为结果。为了纠正早期发育差异并改善神经学结果，有人提出在新生儿重症监护病房（NICU）住院期间播放音乐作为一种听觉丰富手段，对大脑功能和结构发育具有调节作用，但迄今为止尚未研究过此类干预措施的纵向影响。我们对43名早产儿的静息态功能连接（RS-FC）成熟情况进行了纵向研究。对孕33周和40周时获得的扫描数据进行了数据驱动的独立成分分析（ICA），以确定不同静息态网络（RSN）的存在。连接组分析“一致性度量”对孕33周和40周时的RS-FC进行了定量检查。进一步比较孕33周和40周时网络间的RS-FC，得到了一个感兴趣的电路（COI），用于检测显著成熟变化，其中测试了音乐干预对RS-FC的影响。连接组分析结果显示，从孕33周到40周，RS-FC连接的COI显著成熟，即丘脑/脑干与前额叶-边缘、突显、感觉运动、听觉和前额叶皮质网络之间；前额叶-边缘与小脑、视觉和左半球楔前叶网络之间；突显与视觉和小脑网络之间；以及感觉运动与听觉、后扣带回/楔前叶网络之间。与对照组相比，接触音乐的婴儿丘脑/脑干与突显网络之间的RS-FC成熟度显著增加。这项研究表明，通过NICU音乐暴露可调节早产儿的RS-FC成熟度，突出了环境丰富化对早产新生儿神经发育的重要性。
