Rogan W J, Yang G C, Kimbrough R D
Arch Environ Health. 1985 Mar-Apr;40(2):91-5. doi: 10.1080/00039896.1985.10545896.
In order to reinvestigate a strong reported association, we attempted to identify aflatoxin in the livers of 12 children who presumably died of Reye's Syndrome and in the liver of one child who died accidentally. Aflatoxins were detected, but not confirmed in only one of the liver specimens (limits of detection 20 ppt). In addition, the microscopic appearance of the livers was reviewed. Although most of the cases fit the clinical definition of Reye's Syndrome, the microscopic appearance of the liver was varied. We conclude that aflatoxin is not regularly recoverable from cases of Reye's Syndrome at a high rate, and question the proposed etiologic relationship. We confirm the varied appearance of the liver late in the course of Reye's Syndrome; however, microvesicular fat was present in most cases.
为了再次研究一项有大量报告的关联，我们试图在12名据推测死于瑞氏综合征的儿童肝脏以及1名意外死亡儿童的肝脏中鉴定黄曲霉毒素。检测到了黄曲霉毒素，但仅在一份肝脏标本中得到证实（检测限为20ppt）。此外，对肝脏的微观表现进行了复查。尽管大多数病例符合瑞氏综合征的临床定义，但肝脏的微观表现各不相同。我们得出结论，在瑞氏综合征病例中不能经常以高比率检测到黄曲霉毒素，并对所提出的病因关系提出质疑。我们证实了瑞氏综合征病程后期肝脏表现各异；然而，大多数病例中存在微泡性脂肪。
