Zhang Xinyi, Zhou Kemeng, Zhao Zhangjin, Lin Yuanjing
School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China.
Adv Mater. 2025 Mar 5:e2418729. doi: 10.1002/adma.202418729.
Photonic materials possess tunable optical properties and have been widely utilized for healthcare applications. These materials enable the detection of physical and physiological bio-signals via modulated optical output characteristics, such as wavelength shifts, fluorescence emission, and light scattering. When further synthesized into functional photonic inks, multimodal devices for epidermal, minimally invasive, and implantable bio-sensing can be constructed in facile and printable manners. This review first introduces functional photonic materials in different geometries and their unique properties. To enable feasible fabrication of multi-functional photonic devices for biosensing in versatile platforms, the synthesis of printable inks and the as-printed devices are then illustrated. Subsequently, the advances and breakthroughs to construct printable photonic devices and integrated systems for wearable and implantable applications are displayed, especially for multimodal sensing to facilitate personalized and remote healthcare. Finally, the challenges in achieving mechanical stability, eliminated degradation, enhanced biocompatibility in dynamic biological environments, and scalable production are discussed, along with the prospects toward reliable and intelligent healthcare.
光子材料具有可调节的光学特性，已被广泛应用于医疗保健领域。这些材料能够通过调制光学输出特性，如波长偏移、荧光发射和光散射，来检测物理和生理生物信号。当进一步合成功能性光子墨水时，可以以简便且可打印的方式构建用于表皮、微创和可植入生物传感的多模态设备。本综述首先介绍了不同几何形状的功能性光子材料及其独特性质。为了在通用平台上实现用于生物传感的多功能光子器件的可行制造，随后阐述了可打印墨水和打印后器件的合成。接着展示了构建用于可穿戴和可植入应用的可打印光子器件及集成系统的进展和突破，特别是用于多模态传感以促进个性化和远程医疗保健。最后，讨论了在实现机械稳定性、消除降解、增强在动态生物环境中的生物相容性以及可扩展生产方面所面临的挑战，以及可靠和智能医疗保健的前景。
