Erman B A, Tulakina L G, Zubenko A V, Subbotina L S
Arkh Patol. 1985;47(3):46-52.
The central nervous system of monkeys with chronic tick-borne encephalitis (TBE) shows the following ultrastructural alterations which differ from those in acute TBE: widespread destructive changes in neurons, astrocytes, oligodendrocytes, processes, myelin, vascular walls, severe edema of brain tissue with the signs of a so-called spongious degeneration and the absence of cell proliferation and perivascular cell infiltrations, glial nodules as well as circulatory disorders (hyperemia, stasis, hemorrhages). Few virions with or without and altered supercapsid membrane are detected in the neuronal cytoplasm or in the intercellular spaces; the signs of active virus reproduction in the cells are lacking. Pathologic process is of a degenerative but not of an inflammatory nature; the latter is typical for acute TBE.
患有慢性蜱传脑炎（TBE）的猴子的中枢神经系统呈现出以下超微结构改变，这些改变与急性TBE不同：神经元、星形胶质细胞、少突胶质细胞、突起、髓鞘、血管壁广泛的破坏性变化，脑组织严重水肿并有所谓海绵状变性的迹象，且无细胞增殖和血管周围细胞浸润、胶质结节以及循环障碍（充血、淤血、出血）。在神经元细胞质或细胞间隙中很少检测到带有或不带有改变的外衣膜的病毒粒子；细胞中缺乏病毒活跃繁殖的迹象。病理过程是退行性的而非炎症性的；后者是急性TBE的典型特征。
