Han Huan, Xiong Hui, Liu Zengli, Liu Xunzhi, Wang Hailin, Kou Jiaxiang, Yi Dewei, Shi Ying, Wu Hao, Qiao Jianjun
School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Zhejiang Institute of Tianjin University, Shaoxing, China.
Front Microbiol. 2025 Feb 19;16:1542522. doi: 10.3389/fmicb.2025.1542522. eCollection 2025.
(), known as a next-generation probiotic, has been widely recognized for its beneficial effects in various metabolic diseases. While there is not much research whether live or pasteurized has different effects on intestinal health.
In the present study, a strain of was isolated from healthy individuals, with the live and pasteurized named Timepie001 and Timepie001+, respectively. They were administered to dextran sulfate sodium-induced ulcerative colitis mice to investigate their influences on the host intestinal health.
The results showed that prophylactic supplementation with live and pasteurized alleviates ulcerative colitis symptoms by retarding weight loss, preserving intestinal tissue structure, modulating inflammatory cytokines (TNF-α, IL-1β), and enhance the colonic mucosal barrier by upregulating the expression of tight junction protein Claudin-1. Interestingly, pasteurized has a better effect compared with live . Moreover, pasteurized can regulates the gut microbiome to maintain intestinal homeostasis. This provides theoretical support for the widespread application of postbiotics in the food industry.
（）作为一种下一代益生菌，因其在各种代谢性疾病中的有益作用而被广泛认可。然而，关于活的或巴氏杀菌的（）对肠道健康是否有不同影响的研究并不多。
在本研究中，从健康个体中分离出一株（），将活的和巴氏杀菌的（）分别命名为Timepie001和Timepie001+。将它们给予葡聚糖硫酸钠诱导的溃疡性结肠炎小鼠，以研究它们对宿主肠道健康的影响。
结果表明，预防性补充活的和巴氏杀菌的（）可通过延缓体重减轻、保持肠道组织结构、调节炎性细胞因子（TNF-α、IL-1β）来减轻溃疡性结肠炎症状，并通过上调紧密连接蛋白Claudin-1的表达增强结肠黏膜屏障。有趣的是，巴氏杀菌的（）比活的（）效果更好。此外，巴氏杀菌的（）可以调节肠道微生物群以维持肠道稳态。这为后生元在食品工业中的广泛应用提供了理论支持。
