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中继投影显微望远镜

Relay-projection microscopic telescopy.

作者信息

Yi Wenjun, Zhu Shuyue, Fu Meicheng, Gu Nan, Qi Junli, Liu Siyu, Zhu Mengjun, Wang Ping, Chen Xin, Zhang Yi, Zhang Hongyu, Xu Yao, Du Junyi, Xiong Peng, Dong Zhaohua, Dong Luobing, Liu Qiong, Li Xiujian

机构信息

College of Science, National University of Defense Technology, Changsha, China.

Xi'an Satellite Control Center, Xi'an, China.

出版信息

Light Sci Appl. 2025 Mar 7;14(1):117. doi: 10.1038/s41377-025-01800-6.

DOI:10.1038/s41377-025-01800-6
PMID:40050280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11885427/
Abstract

The fundamental trade-off between spatial resolution and imaging distance poses a significant challenge for current imaging techniques, such as those used in modern biomedical diagnosis and remote sensing. Here, we introduce a new conceptual method for imaging dynamic amplitude-phase-mixed objects, termed relay-projection microscopic telescopy (rPMT), which fundamentally challenges conventional light collection techniques by employing non-line-of-sight light collection through square-law relay-projection mechanisms. We successfully resolved tiny features measuring 2.76 μm, 22.10 μm, and 35.08 μm for objects positioned at distances of 1019.0 mm, 26.4 m, and 96.0 m, respectively, from single-shot spatial power spectrum images captured on the relay screen; these results demonstrate that the resolution capabilities of rPMT significantly surpass the Abbe diffraction limit of the 25 mm-aperture camera lens at the respective distances, achieving resolution improvement factors of 7.9, 25.4, and 58.2. The rPMT exhibits long-distance, wide-range, high-resolution imaging capabilities that exceed the diffraction limit of the camera lens and the focusing range limit, even when the objects are obscured by a scattering medium. The rPMT enables telescopic imaging from centimeters to beyond hundreds of meters with micrometer-scale resolution using simple devices, including a laser diode, a portable camera, and a diffusely reflecting whiteboard. Unlike contemporary high-resolution imaging techniques, our method does not require labeling reagents, wavefront modulation, synthetic receive aperture, or ptychography scanning, which significantly reduce the complexity of the imaging system and enhance the application practicality. This method holds particular promise for in-vivo label-free dynamic biomedical microscopic imaging diagnosis and remote surveillance of small objects.

摘要

空间分辨率与成像距离之间的基本权衡给当前的成像技术带来了重大挑战,例如现代生物医学诊断和遥感中使用的技术。在此,我们引入了一种用于对动态幅度-相位混合物体进行成像的新概念方法,称为中继投影显微望远镜(rPMT),它通过平方律中继投影机制采用非视线光收集,从根本上挑战了传统的光收集技术。我们通过在中继屏幕上捕获的单次空间功率谱图像,成功分辨出分别位于1019.0毫米、26.4米和96.0米距离处的物体上尺寸为2.76微米、22.10微米和35.08微米的微小特征;这些结果表明,在各自距离下,rPMT的分辨率能力显著超过了25毫米孔径相机镜头的阿贝衍射极限,实现了7.9、25.4和58.2的分辨率提升因子。即使物体被散射介质遮挡,rPMT仍展现出超越相机镜头衍射极限和聚焦范围限制的长距离、宽范围、高分辨率成像能力。rPMT使用包括激光二极管、便携式相机和漫反射白板在内的简单设备,能够以微米级分辨率实现从厘米到数百米以上的望远成像。与当代高分辨率成像技术不同,我们的方法不需要标记试剂、波前调制、合成接收孔径或叠层成像扫描,这显著降低了成像系统的复杂性并增强了应用实用性。该方法在体内无标记动态生物医学显微成像诊断和小物体远程监测方面具有特别的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/800806a6b918/41377_2025_1800_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/864e7ea1ce2f/41377_2025_1800_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/acd7a6eb7ffa/41377_2025_1800_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/4e637770c5e9/41377_2025_1800_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/210dcc6f70a8/41377_2025_1800_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/800806a6b918/41377_2025_1800_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/864e7ea1ce2f/41377_2025_1800_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/acd7a6eb7ffa/41377_2025_1800_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/4e637770c5e9/41377_2025_1800_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/210dcc6f70a8/41377_2025_1800_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11885427/800806a6b918/41377_2025_1800_Fig5_HTML.jpg

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本文引用的文献

1
Label-free biomedical optical imaging.无标记生物医学光学成像。
Nat Photonics. 2023 Dec;17(12):1031-1041. doi: 10.1038/s41566-023-01299-6. Epub 2023 Nov 16.
2
Why optics needs thickness.为何光学需要厚度。
Science. 2023 Jan 6;379(6627):41-45. doi: 10.1126/science.ade3395. Epub 2023 Jan 5.
3
High-resolution multi-wavelength lensless diffraction imaging with adaptive dispersion correction.具有自适应色散校正的高分辨率多波长无透镜衍射成像。
Opt Express. 2021 Mar 1;29(5):7197-7209. doi: 10.1364/OE.419128.
4
WISH: wavefront imaging sensor with high resolution.WISH:高分辨率波前成像传感器。
Light Sci Appl. 2019 May 1;8:44. doi: 10.1038/s41377-019-0154-x. eCollection 2019.
5
Near-field Fourier ptychography: super-resolution phase retrieval via speckle illumination.近场傅里叶叠层成像术:通过散斑照明实现超分辨率相位恢复
Opt Express. 2019 Mar 4;27(5):7498-7512. doi: 10.1364/OE.27.007498.
6
Single-shot coherent power-spectrum imaging of objects hidden by opaque scattering media.对被不透明散射介质遮挡物体的单次相干功率谱成像。
Appl Opt. 2019 Feb 1;58(4):1033-1039. doi: 10.1364/AO.58.001033.
7
Super-resolution microscopy demystified.超分辨率显微镜解析。
Nat Cell Biol. 2019 Jan;21(1):72-84. doi: 10.1038/s41556-018-0251-8. Epub 2019 Jan 2.
8
Wide field fluorescence epi-microscopy behind a scattering medium enabled by speckle correlations.基于散斑相关性实现的散射介质后宽场荧光落射显微镜。
Opt Express. 2018 Apr 16;26(8):9866-9881. doi: 10.1364/OE.26.009866.
9
Lensless light-field imaging with Fresnel zone aperture: quasi-coherent coding.具有菲涅耳区孔径的无透镜光场成像:准相干编码
Appl Opt. 2018 Apr 10;57(11):2841-2850. doi: 10.1364/AO.57.002841.
10
Super-Resolution Structured Illumination Microscopy.超分辨率结构光照明显微镜技术。
Chem Rev. 2017 Dec 13;117(23):13890-13908. doi: 10.1021/acs.chemrev.7b00218. Epub 2017 Nov 10.