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碳离子刺激疗法可逆转铁沉积和小胶质细胞驱动的神经炎症，并在阿尔茨海默病小鼠模型中诱导认知改善。

Carbon ion stimulation therapy reverses iron deposits and microglia driven neuroinflammation and induces cognitive improvement in an Alzheimer's disease mouse model.

作者信息

Lee Won-Seok, Kokubo Toshiaki, Choi Younshick, Hamano Tsuyoshi, Zaboronok Alexander, Ishikawa Takaaki, Kwon Oh-Dae, Kim EunHo, Kim Jong-Ki

机构信息

Department of Biochemistry, Daegu Catholic University, Daegu, 42472, South Korea.

HIMAC, QST, Chiba, Japan.

出版信息

Sci Rep. 2025 Mar 7;15(1):7938. doi: 10.1038/s41598-025-91689-3.

DOI:10.1038/s41598-025-91689-3
PMID:40050677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11885615/
Abstract

Insoluble iron deposits often exist as iron oxide nanoparticles in protein aggregates, impaired ferritin, or activated microglia and have been implicated as major causes of neuroinflammation in Alzheimer's disease. However, no crucial evidence has been reported to support the therapeutic effects of current iron chelators on the deposition of various molecular forms of insoluble iron. We investigated the therapeutic effect of carbon ion stimulation (CIS) via a transmission beam on insoluble iron deposits, iron inclusion bodies, and the associated biological response in 5xFAD AD mouse brains. Compared with no treatment, CIS dose-dependently induced a 33-60% reduction in the amount of ferrous-containing iron species and associated inclusion bodies in the brains of AD mice. CIS induced considerable neuroinflammation downregulation and, conversely, anti-inflammatory upregulation, which was associated with improved memory and enhanced hippocampal neurogenesis. In conclusion, our results suggest that the effective degradation of insoluble iron deposits in combination with pathogenic inclusion bodies promotes AD-modifying properties and offers a potential CIS treatment option for AD.

摘要

不溶性铁沉积物通常以氧化铁纳米颗粒的形式存在于蛋白质聚集体、受损的铁蛋白或活化的小胶质细胞中，并被认为是阿尔茨海默病神经炎症的主要原因。然而，尚未有关键证据支持当前铁螯合剂对各种分子形式的不溶性铁沉积的治疗效果。我们研究了通过透射束进行碳离子刺激（CIS）对5xFAD AD小鼠大脑中不溶性铁沉积物、铁包涵体及相关生物学反应的治疗效果。与未治疗相比，CIS剂量依赖性地使AD小鼠大脑中含铁亚铁物种和相关包涵体的数量减少了33%-60%。CIS诱导了显著的神经炎症下调，反之，抗炎上调，这与记忆力改善和海马神经发生增强有关。总之，我们的结果表明，不溶性铁沉积物与致病性包涵体的有效降解相结合可促进AD改善特性，并为AD提供了一种潜在的CIS治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/9292ab17dd5d/41598_2025_91689_Fig9_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/f4631a38179c/41598_2025_91689_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/9292ab17dd5d/41598_2025_91689_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/f10523e07ab0/41598_2025_91689_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/9f4aff85c196/41598_2025_91689_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/42f2d72576ab/41598_2025_91689_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/77f61d69566a/41598_2025_91689_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/9340ecb6068d/41598_2025_91689_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/a9e28f0295c5/41598_2025_91689_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/f4631a38179c/41598_2025_91689_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c633/11885615/9292ab17dd5d/41598_2025_91689_Fig9_HTML.jpg

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