Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Department of Pharmacy, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China.
J Nanobiotechnology. 2024 Jun 18;22(1):343. doi: 10.1186/s12951-024-02627-w.
The use of nanomaterials in gene editing and synthetic biology has emerged as a pivotal strategy in the pursuit of refined treatment methodologies for pulmonary disorders. This review discusses the utilization of nanomaterial-assisted gene editing tools and synthetic biology techniques to promote the development of more precise and efficient treatments for pulmonary diseases. First, we briefly outline the characterization of the respiratory system and succinctly describe the principal applications of diverse nanomaterials in lung ailment treatment. Second, we elaborate on gene-editing tools, their configurations, and assorted delivery methods, while delving into the present state of nanomaterial-facilitated gene-editing interventions for a spectrum of pulmonary diseases. Subsequently, we briefly expound on synthetic biology and its deployment in biomedicine, focusing on research advances in the diagnosis and treatment of pulmonary conditions against the backdrop of the coronavirus disease 2019 pandemic. Finally, we summarize the extant lacunae in current research and delineate prospects for advancement in this domain. This holistic approach augments the development of pioneering solutions in lung disease treatment, thereby endowing patients with more efficacious and personalized therapeutic alternatives.
纳米材料在基因编辑和合成生物学中的应用，已经成为追求肺部疾病精细化治疗方法的关键策略。本综述讨论了利用纳米材料辅助的基因编辑工具和合成生物学技术，以促进更精确和高效的肺部疾病治疗方法的发展。首先，我们简要概述了呼吸系统的特征，并简要描述了各种纳米材料在肺部疾病治疗中的主要应用。其次，我们详细介绍了基因编辑工具、它们的结构和各种传递方法，同时深入研究了纳米材料辅助的基因编辑干预在一系列肺部疾病中的现状。随后，我们简要阐述了合成生物学及其在生物医学中的应用，重点介绍了在 2019 年冠状病毒病大流行背景下，针对肺部疾病的诊断和治疗的研究进展。最后，我们总结了当前研究中的现存空白，并描绘了该领域的发展前景。这种全面的方法增强了在肺部疾病治疗方面开创性解决方案的发展，从而为患者提供更有效和个性化的治疗选择。
