Zhu Yucheng, Zhuang Weisi, Cheng Hao
Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, United States.
Langmuir. 2025 Mar 18;41(10):6457-6470. doi: 10.1021/acs.langmuir.4c04636. Epub 2025 Mar 7.
Therapeutic proteins play a crucial role in modern healthcare. However, the rapid clearance of proteins in the circulation system poses a significant threat to their therapeutic efficacy. The generation of anti-drug antibodies expedites drug clearance, resulting in another challenge to overcome in protein delivery. Several methods to increase the circulation half-lives of these proteins and to minimize their immunogenicity have been developed. This Review discusses the causes of protein clearance in the body, evaluates the FDA-approved strategies to prolong protein circulation, and highlights recent progress in the field. Additionally, the strengths and drawbacks of these methods and our perspectives for advancing protein delivery are provided.
治疗性蛋白质在现代医疗保健中发挥着至关重要的作用。然而，蛋白质在循环系统中的快速清除对其治疗效果构成了重大威胁。抗药物抗体的产生加速了药物清除，这成为蛋白质递送中另一个需要克服的挑战。已经开发了几种方法来延长这些蛋白质的循环半衰期并使其免疫原性最小化。本综述讨论了体内蛋白质清除的原因，评估了美国食品药品监督管理局（FDA）批准的延长蛋白质循环的策略，并强调了该领域的最新进展。此外，还介绍了这些方法的优缺点以及我们对推进蛋白质递送的展望。
