Veronese Francesco M, Pasut Gianfranco
Department of Pharmaceutical Sciences, Padua University, Italy.
Drug Discov Today. 2005 Nov 1;10(21):1451-8. doi: 10.1016/S1359-6446(05)03575-0.
PEGylation defines the modification of a protein, peptide or non-peptide molecule by the linking of one or more polyethylene glycol (PEG) chains. This polymer is non-toxic, non-immunogenic, non-antigenic, highly soluble in water and FDA approved. The PEG-drug conjugates have several advantages: a prolonged residence in body, a decreased degradation by metabolic enzymes and a reduction or elimination of protein immunogenicity. Thanks to these favorable properties, PEGylation now plays an important role in drug delivery, enhancing the potentials of peptides and proteins as therapeutic agents.
聚乙二醇化是指通过连接一个或多个聚乙二醇（PEG）链对蛋白质、肽或非肽分子进行修饰。这种聚合物无毒、无免疫原性、无抗原性，高度溶于水且已获美国食品药品监督管理局批准。聚乙二醇化药物偶联物具有多个优点：在体内的停留时间延长、代谢酶导致的降解减少以及蛋白质免疫原性的降低或消除。由于这些有利特性，聚乙二醇化目前在药物递送中发挥着重要作用，增强了肽和蛋白质作为治疗剂的潜力。
