Li Xiaochun, Liu Yanting, Wu Xuewan, Huang Rui, Chen Shaoqi, Yuan Kaisong
Department of Ultrasound, First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Bio-Analytical Laboratory, Shantou University Medical College, Shantou, 515041, China.
Mikrochim Acta. 2025 Mar 7;192(4):215. doi: 10.1007/s00604-025-07042-y.
As a kind of mechanical wave, ultrasound has been widely employed in the biomedical field due to its superiors of deep tissue penetration, non-destructiveness and non-toxicity. In this review, we highlight current progress and prospects in using ultrasound as a powerful tool for disease treatment and medical imaging, including (1) ultrasound as energy input for driving nano/micromotor in drug delivery, this part first introduces the synthesis and motion behavior of nano/micromotors, then reviews the small molecular and macromolecular compounds that the nano/micromotors are delivering; (2) sonosensitive nanomaterials for disease therapy, the sonodynamic, sonopiezoelectric, sonothermal, and sonomechanical therapy will all be covered; (3) ultrasound as a non-invasive technique for nano/micromotor tracking or medical imaging; (4) the sonoporation of nano/microbubble. Future challenges in using ultrasound for disease treatment or medical imaging will also be described in the conclusion part.
作为一种机械波，超声波因其具有深部组织穿透性、非破坏性和无毒性等优势，已在生物医学领域得到广泛应用。在本综述中，我们重点介绍了将超声波用作疾病治疗和医学成像的强大工具的当前进展和前景，包括：（1）超声波作为驱动纳米/微米马达进行药物递送的能量输入，此部分首先介绍纳米/微米马达的合成及运动行为，然后综述纳米/微米马达所递送的小分子和大分子化合物；（2）用于疾病治疗的声敏纳米材料，涵盖声动力治疗、声压电治疗、声热治疗和声机械治疗；（3）超声波作为用于纳米/微米马达追踪或医学成像的非侵入性技术；（4）纳米/微泡的声孔效应。结论部分还将阐述在使用超声波进行疾病治疗或医学成像方面未来面临的挑战。
