Csiba L, Paschen W, Mies G
Brain Res. 1985 Jun 10;336(1):167-70. doi: 10.1016/0006-8993(85)90430-5.
After eliciting a single passage of spreading depression in rat brain cortex, regional alterations in glucose content and tissue pH were studied in relation to changes in cortical steady potential. Migration of spreading depression into non-invaded cortex was accompanied by a drastic decrease in glucose concentration and tissue pH which persisted longer than the transient depolarization of cortical cells. This delay in metabolic recovery is probably accounted for by severe tissue acidosis which results from the stimulation of anaerobic glycolysis.
在诱发大鼠大脑皮层单次扩散性抑制后，研究了葡萄糖含量和组织pH值的区域变化与皮层稳定电位变化的关系。扩散性抑制向未受侵袭的皮层迁移时，伴随着葡萄糖浓度和组织pH值的急剧下降，这种下降持续的时间比皮层细胞的短暂去极化时间更长。代谢恢复的这种延迟可能是由刺激无氧糖酵解导致的严重组织酸中毒引起的。
