Vogh B P, Godman D R
Can J Physiol Pharmacol. 1985 Apr;63(4):340-3. doi: 10.1139/y85-061.
Administration iv of 50 mg X kg-1 acetazolamide (A) and 3 mg X kg-1 timolol (T) causes the formation of cerebrospinal fluid (f-CSF) to be reduced to 43.7% of the control rate compared with a reduction to 82.5% of control by T alone and to 52.6% of control by A alone. The effect of combined drugs is the same when A is combined with T initially, when A is added to T after studying T alone, or when T is added to A after studying A alone. In contrast, in rats f-CSF is not influenced by T, either alone or when in combination with A. The rate in rats is reduced to 55% of control by treatments with A or A and T. Decrease in formation of cerebrospinal fluid by A occurs through inhibition of carbonic anhydrase, but the means whereby T (a known blocker of beta-adrenergic receptors) causes a reduction in f-CSF is not established; it is known that it does not inhibit carbonic anhydrase. Control of f-CSF by the sympathetic nervous system is discussed.
静脉注射50毫克/千克的乙酰唑胺（A）和3毫克/千克的噻吗洛尔（T），会使脑脊液生成量（f-CSF）降至对照率的43.7%，而单独使用T时可降至对照率的82.5%，单独使用A时可降至对照率的52.6%。当A与T最初联合使用、在单独研究T后添加A或在单独研究A后添加T时，联合用药的效果相同。相比之下，在大鼠中，f-CSF不受T单独影响，也不受其与A联合使用的影响。用A或A与T处理后，大鼠的脑脊液生成率降至对照率的55%。A通过抑制碳酸酐酶降低脑脊液生成，但T（一种已知的β-肾上腺素能受体阻滞剂）降低f-CSF的机制尚未明确；已知它不抑制碳酸酐酶。文中讨论了交感神经系统对f-CSF的控制。
