Melby J M, Miner L C, Reed D J
Can J Physiol Pharmacol. 1982 Mar;60(3):405-9. doi: 10.1139/y82-059.
The effect of acetazolamide and furosemide on choroid plexus (CP) production and electrolyte composition of cerebrospinal fluid (CSF) from the cat CP in situ was investigated. Both drugs decreased CSF production by the CP by 50--90% from a control rate of 0.53 microL . min-1 . mg-1 CP within 1.5--2.5 h after the start of drug treatment. The results were similar whether the drug was administered intravenously or applied directly to the CSF side of the CP. A number of experiments in which the effect of administering drugs via the chamber were studied were continued with the drugs removed by washing the preparation with drug-free artificial CSF and the responses measured. The results demonstrated that the effects of acetazolamide and furosemide were reversed during the 1st h following the washout. Both drugs decreased K concentration of nascent CSF when administered intravenously and furosemide also did so when administered on the CSF side of the CP. It is concluded from these and previous data that acetazolamide and furosemide markedly inhibit the transport mechanism(s) in the cat CP that are responsible for CP secretion which represents about 40--60% of the total CSF production and that K transport is also affected.
研究了乙酰唑胺和呋塞米对猫原位脉络丛（CP）产生脑脊液（CSF）的影响以及对CSF电解质组成的影响。两种药物在开始药物治疗后的1.5至2.5小时内，使CP产生的CSF量从0.53微升·分钟-1·毫克-1 CP的对照速率降低了50%-90%。无论药物是静脉注射还是直接应用于CP的CSF侧，结果都是相似的。进行了一些通过腔室给药的实验，在用药后用无药人工脑脊液冲洗制剂以去除药物，并测量反应。结果表明，在冲洗后的第1小时内，乙酰唑胺和呋塞米的作用被逆转。静脉注射时，两种药物均降低了新生CSF中的钾浓度，呋塞米应用于CP的CSF侧时也有此作用。根据这些数据和先前的数据得出结论，乙酰唑胺和呋塞米显著抑制猫CP中负责CP分泌的转运机制，CP分泌约占CSF总产量的40%-60%，并且钾转运也受到影响。
