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增强子结合作为禁食反应的关键因素。

Enhancer binding as a KEysTONE of fasting response.

作者信息

Henneman Nathaniel F, Panasyuk Ganna

机构信息

Institut Necker-Enfants Malades, INSERM U1151/CNRS UMR 8253; Paris, 75015, France; Université de Paris Cité; Paris, 75006, France.

Institut Necker-Enfants Malades, INSERM U1151/CNRS UMR 8253; Paris, 75015, France; Université de Paris Cité; Paris, 75006, France.

出版信息

Trends Endocrinol Metab. 2025 Apr;36(4):298-300. doi: 10.1016/j.tem.2025.02.002. Epub 2025 Mar 8.

DOI:10.1016/j.tem.2025.02.002
PMID:40057442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11979617/
Abstract

Fasting is a recurrent daily energy stress that benefits healthspan and lifespan. While ketones fuel fasting in vertebrates, the underlying transcriptional mechanism remains incompletely understood. Recently, Korenfeld et al. revealed peroxisome proliferator-activated receptor alpha (PPARα)-dependent enhancer priming as a keystone for ketone production, increasing our understanding of mechanisms underlying metabolic benefits of alternate-day fasting (ADF).

摘要

禁食是一种反复出现的日常能量应激，对健康寿命和寿命有益。虽然酮类为脊椎动物的禁食提供能量，但其潜在的转录机制仍未完全了解。最近，科伦菲尔德等人揭示了过氧化物酶体增殖物激活受体α（PPARα）依赖性增强子引发是酮生成的关键，这增加了我们对隔日禁食（ADF）代谢益处潜在机制的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa95/11979617/1191d0e65a10/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa95/11979617/1191d0e65a10/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa95/11979617/1191d0e65a10/gr1.jpg

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2
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本文引用的文献

1
Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis.反复禁食会使增强子、转录因子活性和基因表达敏感化，以支持增强的生酮作用。
Nucleic Acids Res. 2025 Jan 7;53(1). doi: 10.1093/nar/gkae1161.
2
Adipose tissue retains an epigenetic memory of obesity after weight loss.减肥后，脂肪组织保留了肥胖的表观遗传记忆。
Nature. 2024 Dec;636(8042):457-465. doi: 10.1038/s41586-024-08165-7. Epub 2024 Nov 18.
3
A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites.
一条β-羟基丁酸分流途径产生抗肥胖的酮类代谢产物。
Cell. 2025 Jan 9;188(1):175-186.e20. doi: 10.1016/j.cell.2024.10.032. Epub 2024 Nov 12.
4
Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake.肝迷走传入神经传递与时钟相关的信号以调节昼夜节律性摄食。
Science. 2024 Nov 8;386(6722):673-677. doi: 10.1126/science.adn2786. Epub 2024 Nov 7.
5
Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver.食物感知促进肝脏中 MFFS131 的磷酸化和线粒体碎片化。
Science. 2024 Apr 26;384(6694):438-446. doi: 10.1126/science.adk1005. Epub 2024 Apr 25.
6
An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver.一个控制生物钟成分凝聚和肝脏节律性转录的无序区域。
Mol Cell. 2023 Oct 5;83(19):3457-3469.e7. doi: 10.1016/j.molcel.2023.09.010.
7
Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice.限时进食起始时间与生物钟同步可延长雄性 C57BL/6J 小鼠寿命。
Science. 2022 Jun 10;376(6598):1192-1202. doi: 10.1126/science.abk0297. Epub 2022 May 5.
8
Antiaging diets: Separating fact from fiction.抗衰老饮食：区分事实与虚构。
Science. 2021 Nov 19;374(6570):eabe7365. doi: 10.1126/science.abe7365.
9
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice.禁食可增强限制热量摄入对小鼠代谢、分子和抗衰老作用。
Nat Metab. 2021 Oct;3(10):1327-1341. doi: 10.1038/s42255-021-00466-9. Epub 2021 Oct 18.
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Sex- and age-dependent outcomes of 9-hour time-restricted feeding of a Western high-fat high-sucrose diet in C57BL/6J mice.9 小时限时进食西式高脂肪高蔗糖饮食对 C57BL/6J 小鼠的性别和年龄依赖性影响。
Cell Rep. 2021 Aug 17;36(7):109543. doi: 10.1016/j.celrep.2021.109543.