艾滋病毒感染者中猴痘疫苗接受度和犹豫情况的流行率：一项全面的系统评价和荟萃分析。

Prevalence of Mpox vaccine acceptance and hesitancy among people living with HIV: a comprehensive systematic review and meta-analysis.

作者信息

Yappalparvi Ambanna, Khatib Mahalaqua Nazli, Balaraman Ashok Kumar, Rekha M M, Kaur Mandeep, Sharma Girish Chandra, Sudan Puneet, Naidu K Satyam, Singh Rajesh, Ramashankar Sonam, Khati Karan, Chauhan Sanjay Singh, Verma Lokesh, Sidhu Amritpal, Mehta Rachana, Sah Renu, Gaidhane Abhay M, Shabil Muhammed, Chipeta Joseph Clement, Bushi Ganesh

机构信息

Noida Institute of Engineering and Technology (Pharmacy Institute), Greater, Noida, India.

Research and Enterprise, University of Cyberjaya, Persiaran Bestari, Cyber 11, Cyberjaya, Selangor, 63000, Malaysia.

出版信息

AIDS Res Ther. 2025 Mar 8;22(1):31. doi: 10.1186/s12981-025-00726-8.

DOI:10.1186/s12981-025-00726-8

PMID:40057788

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11889782/

Abstract

BACKGROUND

Vaccine acceptance among People Living with HIV (PLWH) is crucial for managing and mitigating the spread of infectious diseases, including Mpox. This systematic review and meta-analysis assess the rate of vaccine acceptance for Mpox among PLWH and identify factors influencing these rates.

METHODS

We searched major databases including PubMed, Embase, and Web of Science up to 30 August 2024 for observational studies involving PLWH that reported on mpox vaccine acceptance rates. A random-effects model was employed for the meta-analysis, utilizing R software version 4.4. Heterogeneity among the studies was quantified using the I² statistic, and the methodological quality of each study was assessed using a modified version of the Newcastle-Ottawa Scale.

RESULTS

Out of 1,123 articles identified, 17 studies met the inclusion criteria and included 7,248 participants. The pooled estimate of the Mpox vaccine acceptance rate was 61.1% (95% CI: 44.2-75.7%), with high heterogeneity (I² = 99%). Additionally, a pooled vaccine hesitancy prevalence was 13.2%, (95% CI: 2.4-48.6%), reflecting substantial variability and had high heterogeneity (I² = 98%).

CONCLUSION

This systematic review and meta-analysis reveal moderate Mpox vaccine acceptance and considerable hesitancy among PLWH. To further increase vaccine uptake and address any remaining hesitancy in this at-risk population, targeted public health strategies and ongoing research are necessary. Strengthening vaccine acceptance is critical to safeguarding PLWH against emerging infectious diseases such as Mpox.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

艾滋病毒感染者（PLWH）对疫苗的接受程度对于管理和减轻包括猴痘在内的传染病传播至关重要。本系统评价和荟萃分析评估了PLWH中猴痘疫苗的接受率，并确定影响这些率的因素。

方法

我们检索了包括PubMed、Embase和Web of Science在内的主要数据库，截至2024年8月30日，查找涉及报告猴痘疫苗接受率的PLWH的观察性研究。采用随机效应模型进行荟萃分析，使用R软件版本4.4。使用I²统计量对研究间的异质性进行量化，并使用纽卡斯尔-渥太华量表的修改版评估每项研究的方法学质量。

结果

在识别出的1123篇文章中，17项研究符合纳入标准，共纳入7248名参与者。猴痘疫苗接受率的合并估计值为61.1%（95%CI：44.2-75.7%），异质性较高（I²=99%）。此外，疫苗犹豫的合并患病率为13.2%（95%CI：2.4-48.6%），反映出存在很大变异性且异质性较高（I²=98%）。