鼻旁窦癌。一项前瞻性初步研究的结果。

Carcinoma of the paranasal sinuses. Results of a prospective pilot study.

作者信息

Knegt P P, de Jong P C, van Andel J G, de Boer M F, Eykenboom W, van der Schans E

出版信息

Cancer. 1985 Jul 1;56(1):57-62. doi: 10.1002/1097-0142(19850701)56:1<57::aid-cncr2820560110>3.0.co;2-#.

DOI:10.1002/1097-0142(19850701)56:1<57::aid-cncr2820560110>3.0.co;2-#

Abstract

Sixty patients with paranasal sinus cancer were treated from January 1976 until July 1981 according to a standard protocol in which surgery is combined with a low dose of irradiation and a topically applied cytostatic drug. The local control rate was 65%. Mutilation was clearly reduced. The actuarial 2-year and 5-year survival rate was 76% and 65%, respectively. The actuarial 5-year survival rate for squamous cell carcinoma and undifferentiated carcinoma of the maxillary sinus was 52%. For adenocarcinoma of the ethmoid sinus the actuarial 5-year survival rate was 100%. The results of this prospective pilot study suggest that it may be possible to achieve better results with less aggressive treatment.

摘要

1976年1月至1981年7月期间，根据一项标准方案对60例鼻窦癌患者进行了治疗，该方案将手术与低剂量放疗及局部应用细胞抑制药物相结合。局部控制率为65%。致残率明显降低。精算2年和5年生存率分别为76%和65%。上颌窦鳞状细胞癌和未分化癌的精算5年生存率为52%。筛窦腺癌的精算5年生存率为100%。这项前瞻性初步研究的结果表明，采用侵入性较小的治疗方法可能会取得更好的效果。