Miyaguchi M, Sakai S, Olofsson J, Kuwabara H, Sakamoto H
Department of Otolaryngology, Kagawa Medical School, Japan.
Eur Arch Otorhinolaryngol. 1993;249(8):478-81. doi: 10.1007/BF00168859.
The expression of epidermal growth factor receptor (EGFR) was determined immunohistochemically in two groups of maxillary sinus squamous cell carcinomas, one with recurrences at the primary site after combination therapy with radiotherapy, chemotherapy and/or surgery and one without local recurrences. Using a four-graded scale (-, +, + +, + + +), 9 of the 10 recurrent carcinomas had a staining intensity and proportion of stained cells of + + or more. A comparable staining intensity was found in 9 of the 18 non-recurrent carcinomas. This difference is statistically significant (Fisher's exact probability test, P < 0.05). These results indicate that an increased expression of EGFR may influence the recurrence rate of squamous cell carcinoma of the maxillary sinus after combined therapy.
采用免疫组织化学方法测定了两组上颌窦鳞状细胞癌中表皮生长因子受体（EGFR）的表达情况，一组是在接受放疗、化疗和/或手术联合治疗后原发部位出现复发的患者，另一组是未出现局部复发的患者。使用四级评分标准（-、+、++、+++），10例复发性癌中有9例染色强度和染色细胞比例为++或更高。18例非复发性癌中有9例出现了类似的染色强度。这种差异具有统计学意义（Fisher精确概率检验，P<0.05）。这些结果表明，EGFR表达增加可能会影响联合治疗后上颌窦鳞状细胞癌的复发率。
